Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres as carriers for drug delivery

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Yufang ZhuStefan Kaskel

Abstract

Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres with different particle sizes, different mesoporous shell thicknesses, and different levels of Fe(3)O(4) content are prepared by using carbon spheres as templates. The effects of particle size and concentration of Fe(3)O(4)@SiO(2) hollow mesoporous spheres on cell uptake and their in vitro cytotoxicity to HeLa cells are evaluated. The spheres exhibit relatively fast cell uptake. Concentrations of up to 150 microg mL(-1) show no cytotoxicity, whereas a concentration of 200 microg mL(-1) shows a small amount of cytotoxicity after 48 h of incubation. Doxorubicin hydrochloride (DOX), an anticancer drug, is loaded into the Fe(3)O(4)@SiO(2) hollow mesoporous spheres, and the DOX-loaded spheres exhibit a somewhat higher cytotoxicity than free DOX. These results indicate the potential of Fe(3)O(4)@SiO(2) hollow mesoporous spheres for drug loading and delivery into cancer cells to induce cell death.

References

Apr 4, 2003·International Journal of Pharmaceutics·Jaspreet Kaur VasirSanjay Garg
Sep 1, 2004·International Journal of Pharmaceutics·S Freiberg, X X Zhu
Oct 14, 2004·Journal of the American Chemical Society·Daniela R RaduVictor S-Y Lin
Jun 23, 2005·Journal of the American Chemical Society·Wenru ZhaoJianlin Shi
Oct 14, 2006·American Journal of Respiratory Cell and Molecular Biology·Steven R BlumenBrooke T Mossman
Nov 17, 2006·Pharmaceutical Research·V P Torchilin
Jul 17, 2007·Chemical Research in Toxicology·Yuhui JinJulia Xiaojun Zhao
Nov 6, 2007·Current Drug Delivery·Abdus SamadM Aqil
Nov 14, 2007·Chembiochem : a European Journal of Chemical Biology·Si-Han WuChung-Yuan Mou
Feb 19, 2008·Journal of Inorganic Biochemistry·Anthony J Di PasquaTewodros Asefa
Aug 5, 2008·Biomaterials·Sarah P HudsonDaniel S Kohane

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Citations

Sep 13, 2011·ACS Applied Materials & Interfaces·Jun Song ChenXiong Wen David Lou
Aug 2, 2012·ACS Applied Materials & Interfaces·Mi Mi WanJian Hua Zhu
May 28, 2013·ACS Applied Materials & Interfaces·Guixin YangPiaoping Yang
Nov 5, 2011·Journal of the American Chemical Society·Yu-Shen LinChristy L Haynes
Jun 15, 2012·Journal of the American Chemical Society·Hui LiuJun Yang
Jun 28, 2011·Chemical Communications : Chem Comm·Motohiro TagayaJunzo Tanaka
Sep 29, 2011·Chemical Communications : Chem Comm·Bin LiuXinlin Yang
May 16, 2013·International Journal of Nanomedicine·Huijie ZhangNobutaka Hanagata
Jan 18, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Hongri WanChen-Ho Tung
Dec 3, 2014·Journal of Colloid and Interface Science·Jong Woong ParkSang Man Koo
Jan 16, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Changjian LvWeiping Qin
Apr 3, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Yichen ZhuYe Tian
Jun 30, 2014·Colloids and Surfaces. B, Biointerfaces·Zhengyan HuHanfa Zou
May 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chengtie Wu, Jiang Chang
Dec 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jia-Kun XuMi Sun
Jan 30, 2016·Advances in Colloid and Interface Science·Jianglan QuJun Yang
Jan 15, 2013·Journal of Colloid and Interface Science·Jianmei PangYuxia Luan
Jan 17, 2012·Toxicology and Applied Pharmacology·Javed AhmadAbdulaziz A Al-Khedhairy
Jul 7, 2011·Advanced Drug Delivery Reviews·Sudeshna ChandraD Bahadur
Mar 2, 2012·Advanced Materials·Fangqiong TangDong Chen

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