Rattlesnake venom induces apoptosis by stimulating PC-PLC and upregulating the expression of integrin beta4, P53 in vascular endothelial cells

Toxicon : Official Journal of the International Society on Toxinology
Qitao ZhaoJunying Miao

Abstract

In the previous studies, we found that phosphatidylcholine-specific phospholipase C (PC-PLC) was implicated in apoptosis induced by rattlesnake venom in vascular endothelial cells (VEC) [Biochem. Biophys. Res. Commun. (1997b) 223, 182]. In order to find out other signal elements in this pathway and the mechanisms by which PC-PLC mediates apoptosis induced by rattlesnake venom in VEC, the expression of integrin beta4 and P53 was evaluated when the activity of PC-PLC was suppressed by D609 (tricyclodecan-9-yl-xanthogenate), a specific inhibitor of this enzyme. The increase of integrin beta4 and P53 expression induced by the venom was markedly suppressed when apoptosis of VEC was inhibited by D609. The data indicated that integrin beta4 and P53 play important roles in signal transduction of apoptosis induced by rattlesnake venom, and that PC-PLC might regulate apoptosis by up-regulating the expression of integrin beta4 and P53 in VEC.

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Citations

Dec 26, 2015·Toxicon : Official Journal of the International Society on Toxinology·Goran GajskiVera Garaj-Vrhovac
Jul 12, 2011·Trends in Cardiovascular Medicine·HaiYing LiJunYing Miao
Dec 9, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zhiwu DongJunying Miao
Apr 6, 2011·Journal of Cellular Physiology·Li WangJunying Miao
May 29, 2010·Journal of Cellular Physiology·ChunHui SunJunYing Miao
Jul 29, 2006·Bioorganic & Medicinal Chemistry Letters·Nan WangJunYing Miao
Oct 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hongzhuan XuanFuliang Hu
Oct 29, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·Hongzhuan XuanFuliang Hu
Jan 12, 2016·Journal of Cardiovascular Pharmacology·ShuYan LiuJunYing Miao
Mar 3, 2009·Biochimica Et Biophysica Acta·Julie C RobichaudDennis E Vance
May 12, 2010·Journal of Cellular Physiology·Ning MengJunYing Miao
Jan 8, 2008·The Journal of Biological Chemistry·Carlos MinahkDennis E Vance

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