PMID: 59126Jul 3, 1976

Rauwolfia derivatives and breast cancer in hypertensive women

B ArmstrongR Doll


Three groups of women were selected from a sample of death certificates that had been coded by the Office of Population Censuses and Surveys for all conditions mentioned on them: (1) all women with reference to both breast cancer and hypertension; (2) all women with reference to hypertension and other cancers; (3) a group of women with reference to hypertension without cancer, selected to match the breast-cancer patients with respect to five features. When the women with breast cancer were compared with both the women with other cancers and the women without cancer, there was a positive association between breast cancer and the use of rauwolfia derivatives, although neither the differences in the frequency nor duration observed were statistically significant. The association appeared to be strongest for use near the time of diagnosis of the cancer. This agrees with nearly all other data and would be expected if rauwolfia derivatives promoted the development of breast cancer from previously initiated cells.


Jun 26, 1975·The New England Journal of Medicine·T M MackM C Pike
Sep 21, 1974·Lancet·O P HeinonenM I Turunen


Jan 3, 1977·European Journal of Clinical Pharmacology·H KewitzE Lindtner
Jul 19, 1977·European Journal of Clinical Pharmacology·L J ChristopherR D Weir
Feb 5, 2008·Journal of Mammary Gland Biology and Neoplasia·Shelley S Tworoger, Susan E Hankinson
May 11, 2002·Current Hypertension Reports·Ehud GrossmanUri Goldbourt
Apr 1, 1979·The American Journal of Medicine·R I Horwitz, A R Feinstein
Jun 1, 1994·Schizophrenia Research·P B Mortensen
Apr 18, 2002·The American Journal of Medicine·Ehud GrossmanUri Goldbourt
Apr 15, 1999·Journal of the National Cancer Institute·Susan E HankinsonF E Speizer
Feb 18, 2003·Endocrine Reviews·Charles V ClevengerLinda A Schuler
Feb 4, 2016·Cell Biology and Toxicology·Miriam E MossobaRobert L Sprando
Jun 1, 1987·Acta Psychiatrica Scandinavica·P B Mortensen
Jan 15, 1977·Lancet·L J ChristopherR D Weir
Jun 1, 1983·European Journal of Cancer & Clinical Oncology·K VerdealD P Rose
Feb 1, 1978·Cancer·D Kodlin, N McCarthy
Oct 1, 1983·British Journal of Clinical Pharmacology·J Crooks
May 9, 2012·Current Opinion in Cardiology·Amita Singh, Sripal Bangalore

Related Concepts

Mammary Neoplasms, Human
Death Records
Hypertensive Disease

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