Ravages of Diabetes on Gastrointestinal Sensory-Motor Function: Implications for Pathophysiology and Treatment

Current Gastroenterology Reports
Hans GregersenJingbo Zhao

Abstract

Symptoms related to functional and sensory abnormalities are frequently encountered in patients with diabetes mellitus. Most symptoms are associated with impaired gastric and intestinal function. In this review, we discuss basic concepts of sensory-motor dysfunction and how they relate to clinical findings and gastrointestinal abnormalities that are commonly seen in diabetes. In addition, we review techniques that are available for investigating the autonomic nervous system, neuroimaging and neurophysiology of sensory-motor function. Such technological advances, while not readily available in the clinical setting, may facilitate stratification and individualization of therapy in diabetic patients in the future. Unraveling the structural, mechanical, and sensory remodeling in diabetes disease is based on a multidisciplinary approach that can bridge the knowledge from a variety of scientific disciplines. The final goal is to increase the understanding of the damage to GI structures and to sensory processing of symptoms, in order to assist clinicians with developing an optimal mechanics based treatment.

References

Feb 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·A DejgaardH H Parving
May 1, 1986·The American Journal of Medicine·S K IyerA Sutton
Oct 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·B Smith
Jul 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·R J GuyP J Watkins
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·S A ZoubiR A Sparrow
Dec 1, 1996·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H Gregersen, G Kassab
Jan 16, 1999·Gastroenterology Clinics of North America·G N Verne, C A Sninsky
May 11, 1999·Digestive Diseases and Sciences·A SpångéusM El-Salhy
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·N T EjskjaerP J Watkins
Sep 7, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·G T KoC S Cockram
Jan 29, 2000·Gastroenterology·M CharltonK S Nair
Mar 17, 2000·Scandinavian Journal of Gastroenterology·J A RicciC E Farup
Jun 26, 2001·Diabetes Care·K L JonesM Horowitz
Jul 27, 2001·Diabetes Care·A I VinikG L Pittenger
Sep 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M A NicosiaL S Miller
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Asbjørn Mohr DrewesLars Arendt-Nielsen
Jul 9, 2002·Journal of Gastroenterology and Hepatology·Masanori NakaharaYuji Matsuzawa
Apr 13, 2004·European Journal of Gastroenterology & Hepatology·Christopher K RaynerMelvin Samsom
Apr 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J YangH Gregersen
Jul 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jens Juul Holst, Jesper Gromada
Jan 22, 2005·Pain·Oshra SedanDavid Yarnitsky
Aug 11, 2005·Gut·A M DrewesL Arendt-Nielsen
May 12, 2006·World Journal of Gastroenterology : WJG·Asbjorn Mohr Drewes, Hans Gregersen
May 24, 2006·World Journal of Gastroenterology : WJG·Jingbo ZhaoNiels Ejskjaer
Sep 5, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Barry P McMahonHans Gregersen
Dec 27, 2006·Journal of Diabetes and Its Complications·Jingbo ZhaoHans Gregersen
Sep 11, 2007·World Journal of Gastroenterology : WJG·Jens Brondum FrokjaerHans Gregersen
Feb 20, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A KumarS S C Rao
Apr 10, 2008·Journal of Gastroenterology and Hepatology·Bridget R Southwell
Apr 16, 2009·Diabetes Care·Jens Brøndum FrøkjaerAsbjørn Mohr Drewes
Jul 2, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X-Y WangL W C Liu
Oct 31, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lin LinJiande D Z Chen
Sep 4, 2010·European Journal of Pain : EJP·Jens Brøndum FrøkjærAsbjørn Mohr Drewes
Oct 14, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B ChandrasekharanS Srinivasan

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