PMID: 9161559Jan 1, 1997Paper

Raynaud syndrome complicated by digital gangrene during treatment with interferon-alpha

La Revue de médecine interne
E LiozonE Vidal

Abstract

In a 43-year old male suffering from idiopathic hypereosinophilic syndrome (HES) since 1984, successfully treated with alpha interferon (alpha IFN) for 32 months, a severe Raynaud's phenomenon of the four extremities occurred and eventually evolved into digital necrosis within a few weeks. The arterial echography/doppler and plethysmography patterns were suggestive of isolated small-to medium-size digital artery occlusions. An extensive search for an aetiology of digital necrosis, including complete tests of autoimmunity, remained negative. Two months later, despite alpha IFN withdrawal and intravenous infusions of ilomedin, the digital ischemia evolved to extensive necrosis that necessitated several amputations and a definitive spinal chord stimulation. Pathologic examination of arteries showed no vasculitis but diffuse arterial occlusions by thrombi.

Citations

Jan 19, 2002·Current Rheumatology Reports·Marta Lucia Cuellar
Mar 9, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·D P Ruiz-GenaoA García-Díez
Apr 16, 2014·American Journal of Therapeutics·Oksana HamidiScott Hasler
Mar 8, 2016·British Journal of Clinical Pharmacology·Charles KhouriMatthieu Roustit
Apr 12, 2003·Leukemia & Lymphoma·H Al-ZahraniJ H Lipton

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