PMID: 8949451Sep 1, 1996Paper

Raynaud's phenomenon and digital necrosis induced by interferon-alpha

The British Journal of Dermatology
C BachmeyerS Aractingi

Abstract

We report two patients treated with interferon-alpha who developed Raynaud's phenomenon followed by multiple digital necrosis. Arteriography of the legs revealed diffuse distal narrowing. Histological examination of the resected tissue showed ischaemic necrosis within the dermis and subcutaneous tissue without vasculitis. Resolution of the symptoms was observed when interferon-alpha was withdrawn. Since other causes of Raynaud's phenomenon and digital necrosis were ruled out, a drug cause is likely. Raynaud's phenomenon should be looked for in patients treated with interferon-alpha. If present, immediate withdrawal of the drug is required.

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Citations

Apr 15, 2004·Burns : Journal of the International Society for Burn Injuries·Safvet Ors
Aug 20, 2009·Pediatric Dermatology·Stacey BrismanKimberly D Morel
Jan 17, 2008·PloS One·Jo N FlemingStephen M Schwartz
Apr 12, 2003·Leukemia & Lymphoma·H Al-ZahraniJ H Lipton
Apr 10, 2012·Pharmacology & Therapeutics·Peter M GeorgeJane A Mitchell
Mar 9, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·D P Ruiz-GenaoA García-Díez
May 18, 2011·World Journal of Gastrointestinal Pharmacology and Therapeutics·Jana G HashashDavid J McAdams

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