Raynaud's phenomenon.

Clinical Medicine : Journal of the Royal College of Physicians of London
Ashraful Haque, Michael Hughes

Abstract

Raynaud's phenomenon (RP) is a common vasospastic condition which affects ~5% of the general population. The majority of individuals have primary RP; however, Raynaud's can also occur secondary to a broad range of underlying medical conditions and drug therapies. RP is a cardinal feature in patients with systemic sclerosis and is often the earliest symptom of the disease. Unlike primary RP, patients with secondary RP can develop persistent digital ischaemia, including ulcers and gangrene. Patients require a comprehensive clinical assessment and investigation, in particular, the detection of autoantibodies and nailfold capillaroscopic abnormalities. Non-pharmacological management is indicated in all patients. There are a wide range of available drug therapies to treat RP, including when complicated by digital ulceration, and surgical intervention is sometimes required. Future research is needed to understand the complex pathogenesis of RP and to measure the impact and severity of RP to develop optimised approaches to management.

References

Mar 3, 2005·Rheumatology·A L Herrick
Apr 13, 2006·Journal des maladies vasculaires·M A PistoriusH Lemarec
Dec 13, 2006·Clinical Rheumatology·Murray BaronSuzanne Taillefer
May 3, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Gülsüm Emel PamukNecati Cakir
Mar 3, 2010·The Journal of Rheumatology·Batsi ChikuraAriane L Herrick
Jul 30, 2011·Rheumatology International·Armen Yuri GasparyanGeorge D Kitas
May 23, 2012·Annals of the Rheumatic Diseases·Florian M P MeierUNKNOWN EUSTAR Co-authors
Jul 12, 2012·Nature Reviews. Rheumatology·Ariane L Herrick
Oct 17, 2013·The Journal of Rheumatology·Vanessa SmithMaurizio Cutolo
May 23, 2015·Annals of the Rheumatic Diseases·Eric HachullaUNKNOWN SEDUCE study group
May 11, 2016·JAMA : the Journal of the American Medical Association·Dinesh KhannaUNKNOWN DUAL-2 Investigators
Jun 11, 2016·Rheumatology·Christopher P DentonUNKNOWN BSR and BHPR Standards, Guidelines and Audit Working Group
Jun 20, 2016·Seminars in Arthritis and Rheumatism·Charlotte A SharpAriane L Herrick
Nov 5, 2016·The Annals of Pharmacotherapy·Joseph E CruzEvelyn R Hermes-DeSantis
Sep 13, 2017·VASA. Zeitschrift für Gefässkrankheiten·Jill BelchZan Zeman
Mar 16, 2018·BMJ : British Medical Journal·Thenappan ThenappanStephen L Archer
Mar 21, 2018·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Izabela Gosk-BierskaMagdalena Koszewicz
Apr 27, 2018·PloS One·Sabrina MunirFrances M K Williams
May 22, 2018·Arthritis & Rheumatology·Andreu Fernández-CodinaUNKNOWN Scleroderma Algorithm Group
Feb 2, 2019·Journal of Scleroderma and Related Disorders·John D PaulingAriane L Herrick
Aug 20, 2019·Clinical Rheumatology·John D PaulingJanet E Pope
Sep 15, 2019·Autoimmunity Reviews·Vanessa SmithUNKNOWN EULAR Study Group on Microcirculation in Rheumatic Diseases
Sep 21, 2019·Current Treatment Options in Rheumatology·Alicia M Hinze, Fredrick M Wigley

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Citations

Jun 7, 2021·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Alekya KothamasuLewis L Hsu

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