Rb binds c-Jun and activates transcription

The EMBO Journal
M A NeadD J McCance

Abstract

The retinoblastoma protein (Rb) acts as a critical cell-cycle regulator and loss of Rb function is associated with a variety of human cancer types. Here we report that Rb binds to members of the AP-1 family of transcription factors, including c-Jun, and stimulates c-Jun transcriptional activity from an AP-1 consensus sequence. The interaction involves the leucine zipper region of c-Jun and the B pocket of Rb as well as a C-terminal domain. We also present evidence that the complexes are found in terminally differentiating keratinocytes and cells entering the G1 phase of the cell cycle after release from serum starvation. The human papillomavirus type 16 E7 protein, which binds to both c-Jun and Rb, inhibits the ability of Rb to activate c-Jun. The results provide evidence of a role for Rb as a transcriptional activator in early G1 and as a potential modulator of c-Jun expression during keratinocyte differentiation.

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J S Lai, W Herr
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Q P DouA B Pardee
Jul 30, 1992·Nature·J R Nevins
Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
Jan 1, 1991·Cold Spring Harbor Symposia on Quantitative Biology·A K RustgiR Bernards
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·F J KayeJ M Horowitz
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L OsbornG J Nabel
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P L ChenW H Lee
Apr 1, 1997·The EMBO Journal·E Bossy-WetzelM Yaniv
May 9, 1997·The Journal of Biological Chemistry·T Zarkowska, S Mittnacht

❮ Previous
Next ❯

Citations

May 22, 2008·Pathology Oncology Research : POR·Ioannis N MammasDemetrios A Spandidos
Dec 22, 1999·Current Opinion in Cell Biology·P Zhang
Feb 13, 2001·Current Opinion in Genetics & Development·L Zhu, A I Skoultchi
Jun 11, 2010·Molecular Biology of the Cell·Keith W VanceColin R Goding
Jan 30, 1999·Genes & Development·P ZhangS J Elledge
Aug 29, 2012·Molecular and Cellular Biology·Michael KorenjakNicholas J Dyson
Aug 25, 2000·Molecular and Cellular Biology·C LemercierS Khochbin
Sep 21, 2002·Molecular and Cellular Biology·Thomas F WestbrookDennis J McCance
Feb 12, 2013·Retrovirology·Mamneet Manghera, Renée N Douville
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·L FajasC Sardet
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·U G BhatW T Beck
Jun 26, 2001·International Journal of Experimental Pathology·H R McMurrayD J McAnce
Dec 17, 2011·FEBS Letters·Diego E Montoya-Durango, Kenneth S Ramos
Jul 14, 2010·Biochimica Et Biophysica Acta·Juan LuMing-Liang He
Jun 15, 2012·The Journal of Investigative Dermatology·Adam PickardDennis J McCance
Nov 5, 2008·Cancer·Martin A WhitesideElizabeth R Unger
Nov 26, 2013·Journal of Cellular and Molecular Medicine·Maria Borrell-PagèsLina Badimon
Mar 10, 2001·Experimental Cell Research·L Zheng, W H Lee
Sep 1, 2000·Seminars in Cancer Biology·D DiCiommoR Bremner
Jul 17, 2004·Endocrine Journal·Yasuto IkeoKiyoshi Hashizume
Jan 26, 2007·Journal of Dental Research·C C R RaginS M Gollin
Jan 8, 2003·International Journal of Cancer. Journal International Du Cancer·Wataru YumitaKiyoshi Hashizume

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.