PMID: 16518285Mar 7, 2006Paper

RBC 6-TGN and hematological parameters in patients with Crohn's disease treated by azathioprine

Gastroentérologie Clinique Et Biologique
Pierre-Nicolas D'HalluinDenis Heresbach

Abstract

The immunosuppressive properties of azathioprine (AZA) are mediated by intracellular metabolism of 6-MP into its active metabolites 6-thiguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP). The aims of this study were to correlate red blood cell (RBC) 6-TGN and hematological parameters and their change in adult patients with Crohn's disease (CD) treated by AZA and to determine independent factors enabling determination of RBC 6-TGN. RBC 6-TGN concentration was determined with high performance liquid chromography (HLPC) performed on 74 hepa-rinized blood samples from 32 patients. Changes of hematological parameters were measured for each RBC 6-TGN concentration. RBC 6-TGN concentration above 235 pmol/8x108 RBC was proposed as the therapeutic level in patients treated by AZA. Correlations between the various parameters were assessed as appropriate. Logistic regression analysis was used to determinate independent variables. P<0.05 was considered significant. There was a positive correlation between RBC 6-TGN and decreased red cell count (DeltaRBC) (r=0.314; P=0.006), platelet count (DeltaPlatelets) (r=0.314; P=0.007), White cell count (DeltaWC) (r=0.241; P=0.04) and neutrophil count (DeltaPMN) (r=0.292; P=0.02). RBC 6-TG...Continue Reading

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Citations

Oct 1, 2010·Journal of Gastroenterology and Hepatology·Peter R Gibson, Richard B Gearry
Mar 9, 2012·Journal of Crohn's & Colitis·Giuseppe CostantinoWalter Fries
Jul 30, 2008·British Journal of Clinical Pharmacology·Ahmed F HawwaJames C McElnay
Sep 23, 2014·Digestive Diseases and Sciences·Uri KopylovErnest G Seidman
Jul 2, 2019·Journal of Pediatric Gastroenterology and Nutrition·Ondrej HradskyJiri Bronsky
Jun 4, 2016·European Journal of Gastroenterology & Hepatology·Romein W G DujardinMark Löwenberg
Oct 1, 2019·Journal of Pediatric Gastroenterology and Nutrition·Ondrej HradskyJiri Bronsky
May 31, 2011·Nutrition·Li JiaPeiman Yang

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