Aug 30, 2008

RBM4: a multifunctional RNA-binding protein

The International Journal of Biochemistry & Cell Biology
M Andrea Markus, Brian J Morris


RBM4, also known as Lark, was described initially as having a role in circadian rhythm control in Drosophila. In the last 5 years data have emerged from studies of mammalian cells. It is now clear that RBM4 is an RNA-binding protein involved in diverse cellular processes that include alternative splicing of pre-mRNA, translation, and RNA silencing. Its structure, similar to other RNA-binding proteins, contains two RNA recognition motifs and a CCHC-type zinc finger. Here we review current information about the function of RBM4 and its localization within the cell. We then speculate about its possible relationship to disease.

  • References17
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Mentioned in this Paper

Establishment and Maintenance of Localization
Zinc Fingers
Benign Neoplasm of Testis
CCNA1 gene
Transcription Repressor/Corepressor
Neoplasm of Uncertain or Unknown Behavior of Testis
Complex (molecular entity)

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