RBP-Jkappa binds to and represses transcription of the p53 tumor suppressor gene

Cell Biology International
Kristy BoggsDavid Reisman

Abstract

The tightly regulated expression of p53 contributes to genomic stability and transcription of the p53 gene is induced prior to cells entering S-phase, possibly as a mechanism to insure a rapid p53 response in the event of DNA damage. We have previously described the cloning of an additional 1000bp of upstream p53 sequences that play a role in the regulated expression of p53, and identified that C/EBPbeta-2 participates in inducing p53 gene expression in a cell cycle regulated fashion. This report deals with the transcriptional regulator, RBP-Jkappa, an essential target of the Notch receptor signaling pathway. It binds to the p53 promoter in a cell cycle regulation fashion and also serves to repress p53 gene expression. We conclude from these findings that the coordinate expression of C/EBPbeta-2 and RBP-Jkappa may be linked to p53 transcription during G(0) and as cells move into S-phase. Because defects in the Notch signaling pathway have been implicated in carcinogenesis, aberrant RBP-Jkappa expression and deregulated regulation of the p53 tumor suppressor could be an important step in some forms of cancers.

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D GinsbergM Oren
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C ReedR G Hoover
Jul 30, 1981·Virology·J Milner, S Milner
Sep 15, 1995·The EMBO Journal·J MosnerW Deppert
Jun 1, 1995·The New England Journal of Medicine·J Prioleau, S J Schnitt
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·U M MollG Riou
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·S R GrossmanE Kieff
Sep 23, 1998·Nature·S BatesK H Vousden
Oct 9, 1998·Genes & Development·C J Sherr
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·J J HsiehS D Hayward
Mar 5, 1999·Cellular and Molecular Life Sciences : CMLS·J Choi, L A Donehower
Mar 5, 1999·Cellular and Molecular Life Sciences : CMLS·D A FreedmanA J Levine
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·W Tao, A J Levine
Dec 1, 2000·Nature·B VogelsteinA J Levine
Nov 21, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J H KangH S Kang
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S P HussainC C Harris
Aug 3, 2002·Nature Reviews. Cancer·Karen H Vousden, Xin Lu
Aug 30, 2002·The Journal of Biological Chemistry·Lynne D Vales, Erika M Friedl
Apr 12, 2003·Seminars in Immunology·Kenji TanigakiTasuku Honjo
Jun 24, 2004·Cell·Guangchao SuiYang Shi
Dec 4, 2004·Nature·Ryan T Phan, Riccardo Dalla-Favera
Jun 3, 2005·Cancer Research·David R HodgeWilliam L Farrar
Nov 17, 2005·Molecular and Cellular Biology·Franz OswaldTilman Borggrefe
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lucio Miele
Jan 25, 2007·The Journal of Biological Chemistry·Kristy Boggs, David Reisman

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Citations

Feb 3, 2011·Molecular & Cellular Proteomics : MCP·Becky Pinjou TsaiMarian L Waterman
Dec 31, 2016·International Journal of Molecular Sciences·Catia GiovanniniLaura Gramantieri
Jul 18, 2009·Nature Reviews. Cancer·G Paolo Dotto

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