RC3/neurogranin structure and expression in the caprine brain in relation to congenital hypothyroidism

Brain Research. Molecular Brain Research
P A PiosikF Baas

Abstract

In view of the profound effects of thyroid hormone deficiency on the central nervous system (CNS), neuronal genes regulated by thyroid hormone could potentially be involved in the development of the CNS. Expression of the neuronal gene RC3/neurogranin was shown to be induced by thyroid hormone in the rat. No data are available on RC3 expression in mammals with prenatal brain development, like humans. To study RC3 mRNA expression in a genetic in vivo model of congenital hypothyroidism, which also resembles the human situation in the timing of brain development relative to birth, we used an inbred strain of congenitally hypothyroid goats. We isolated a cDNA for the caprine RC3 homolog. The deduced amino acid sequence had 99% similarity with the rat and bovine protein sequence. An analysis of the developmental expression of RC3 mRNA levels showed a 3-fold increase between E90 and P0. In situ hybridization analysis showed that in euthyroid goats, the RC3 expression pattern was region-specific and resembled that in rats. However, in contrast to rats, hypothyroid goats showed only a reduced RC3 mRNA expression in the striatum. Hypothyroidism had no effect on RC3 mRNA expression in all other brain regions. T4-treatment of the hypothyr...Continue Reading

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Citations

Dec 13, 1997·Molecular Neurobiology·D D Gerendasy, J G Sutcliffe
Mar 25, 2009·Archives of Environmental Contamination and Toxicology·Yu ChenJill C Sible
Jun 15, 2000·Environmental Health Perspectives·S P Porterfield
May 9, 2006·Biochemical and Biophysical Research Communications·Jingang GuiFwu-Shan Sheu
Aug 29, 2009·The EMBO Journal·Ling ZhongNashaat Z Gerges
Jan 5, 2011·The European Journal of Neuroscience·Ling ZhongNashaat Z Gerges

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