RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta

The FEBS Journal
Gennady ErmakKelvin J A Davies

Abstract

The RCAN1 protein (previously called calcipressin 1 or MCIP1) binds to calcineurin, a serine/threonine phosphatase (PP2B), and inhibits its activity. Here we demonstrate that regulated overexpression of an RCAN1 transgene (this gene was previously called DSCR1 or Adapt78) also stimulates expression of the GSK-3beta kinase, which can antagonize the action of calcineurin. We also show that GSK-3beta is regulated by RCAN1 at a post-transcriptional level. In humans, high RCAN1 expression is found in the brain, where at least two mRNA isoforms have been reported. Therefore, we further investigated expression of the various RCAN1 isoforms, resulting from differential splicing and alternative promotors in human brain. We detected at least three distinct RCAN1s: RCAN1-1 Short at 31 kDa (RCAN1-1S), RCAN1-1 Long at 38 kDa (RCAN1-1 L), and RCAN1-4. Furthermore, the levels of RCAN1-1S, but not RCAN1-1 L or RCAN1-4 correlated with the levels of GSK-3beta. This suggests that RCAN1-1S might induce production of GSK-3beta in vivo. While RCAN1s can regulate calcineurin and GSK-3beta, it has also been shown that calcineurin and GSK-3beta can regulate RCAN1s. Here we propose a new model (incorporating all these findings) in which cells maintain a...Continue Reading

References

Nov 10, 1989·JAMA : the Journal of the American Medical Association·D A EvansJ O Taylor
Feb 1, 1985·Neurology·J A MortimerL M Schuman
Apr 1, 1984·Annals of Neurology·A HeymanT Weinberg
Jun 1, 1997·Archives of Biochemistry and Biophysics·D R CrawfordK J Davies
Sep 28, 1999·Journal of Neuropathology and Experimental Neurology·J J PeiR F Cowburn
Apr 4, 2000·Neurology·Z GuoL A Farrer
Oct 4, 2000·Physiological Reviews·F Rusnak, P Mertz
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·B A RothermelR S Williams
Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Christopher L AntosEric N Olson
May 2, 2002·Cell·Gerald R Crabtree, Eric N Olson
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gennady ErmakKelvin J A Davies
Jun 14, 2002·The Journal of Biological Chemistry·Rick B VegaR Sanders Williams
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Yanlin WangRichard T Lee
Mar 5, 2003·Journal of Cell Science·Bradley W Doble, James R Woodgett
Aug 21, 2003·Free Radical Biology & Medicine·H Y LinDana R Crawford
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Karen T ChangKyung-Tai Min
Jan 1, 2004·Genes & Development·Zoe HiliotiKyle W Cunningham
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gennady ErmakKelvin J A Davies

❮ Previous
Next ❯

Citations

Oct 16, 2013·EMBO Molecular Medicine·Nerea Méndez-BarberoMiguel R Campanero
May 7, 2011·International Journal of Alzheimer's Disease·Karen Janet Smillie, Michael Alan Cousin
Jun 3, 2014·Journal of Cardiovascular Pharmacology·Lijie YanShanling Wang
Dec 11, 2007·Eukaryotic Cell·Jamal Stie, Deborah Fox
May 30, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fei LiuCheng-Xin Gong
Mar 20, 2009·Human Molecular Genetics·Frances K WisemanElizabeth M C Fisher
Oct 1, 2013·Trends in Neurosciences·Karen T ChangKyung-Tai Min
Jan 19, 2013·American Journal of Respiratory Cell and Molecular Biology·Stefanie C HummlerShu Wu
Mar 8, 2013·Seminars in Cell & Developmental Biology·Diane M Bushman, Jerold Chun
Nov 13, 2012·Archives of Medical Research·Ana M CárdenasPablo Caviedes
Jan 8, 2009·Genes, Brain, and Behavior·A SiddiquiK J Gardiner
Jun 13, 2015·Journal of Biomedical Science·Ambreen AsimSarita Agarwal
Feb 2, 2013·Free Radical Biology & Medicine·Gennady Ermak, Kelvin J A Davies
Jul 10, 2012·Ageing Research Reviews·Ludovic MartinFaraj Terro
Apr 8, 2009·Biochimica Et Biophysica Acta·David Maldonado-PérezHenry N Jabbour
Feb 3, 2007·Biochimica Et Biophysica Acta·M Carme MuleroMercè Pérez-Riba
Jul 10, 2016·Antioxidants & Redox Signaling·Vicent Bonet-CostaKelvin J A Davies
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sayaka Sekiya, Atsushi Suzuki
Jun 29, 2007·Molecular and Cellular Neurosciences·Eun Jung LeeKwang Chul Chung
Oct 6, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yili Wu, Weihong Song
Nov 3, 2017·Clinical and Experimental Pharmacology & Physiology·Heshan Peiris, Damien J Keating
Jun 18, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gennady ErmakKelvin J A Davies
Jun 28, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kelvin J A DaviesXavier Estivill
Dec 8, 2017·Journal of Psychopharmacology·Gaëlle NaertTangui Maurice
Nov 10, 2018·Translational Neurodegeneration·Antonella TramutolaFabio Di Domenico
Sep 24, 2020·International Journal of Molecular Sciences·Carmen Martínez-Cué, Noemí Rueda
Feb 9, 2019·Nature Reviews. Neurology·Ira T Lott, Elizabeth Head
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R GongL D Dworkin
Mar 20, 2010·Biochemical Society Transactions·Gloria W C TamSeth G N Grant
Oct 4, 2007·Archives of Biochemistry and Biophysics·Amber N MitchellDana R Crawford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.