Abstract
A stratified approach to medicine aims to identify subgroups of patients who should be managed differently from others. Diabetes is a condition that offers considerable potential for stratification, in areas of drug response, complication risk and rate of progression amongst others. Approaches to stratification can be simple, using clinical phenotyping, or more complex involving genomic and other '-omic' technologies. In this review, I will highlight the utility of measuring endogenous insulin production to aid in diagnosis and appropriate treatment; outline key advances in monogenic diabetes where determining genetic aetiology can result in dramatic changes in treatment, and describe the developments in the field of pharmacogenetics in Type 2 diabetes.
References
Jan 1, 1975·Diabetes·R B Tattersall, S S Fajans
Jun 18, 1970·The New England Journal of Medicine·D S SchalchM H Barlow
Dec 5, 1996·Nature·K YamagataG I Bell
Sep 6, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·E R PearsonA T Hattersley
Oct 25, 2003·Lancet·Ewan R PearsonAndrew T Hattersley
Oct 28, 2003·Diabetes Care·Maggie ShepherdAndrew T Hattersley
Dec 25, 2003·Diabetes·Jerry P PalmerMichael W Steffes
Feb 24, 1951·British Medical Journal·R D LAWRENCE
Apr 30, 2004·The New England Journal of Medicine·Anna L GloynAndrew T Hattersley
Nov 8, 2005·Drug Metabolism and Pharmacokinetics·Naoko KimuraKen-Ichi Inui
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Masato OtsukaYoshinori Moriyama
Aug 4, 2006·The New England Journal of Medicine·Andrey P BabenkoPhilippe Froguel
Aug 4, 2006·The New England Journal of Medicine·Ewan R PearsonUNKNOWN Neonatal Diabetes International Collaborative Group
May 4, 2007·The Journal of Clinical Investigation·Yan ShuKathleen M Giacomini
May 19, 2007·Biochemical Pharmacology·Yuko TaniharaKen-Ichi Inui
Oct 2, 2009·Clinical Pharmacology and Therapeutics·K ZhouE R Pearson
Dec 28, 2010·Nature Genetics·UNKNOWN GoDARTS and UKPDS Diabetes Pharmacogenetics Study GroupEwan R Pearson
Oct 13, 2011·Pharmacogenetics and Genomics·Mette M H ChristensenKim Brosen
Mar 29, 2012·Diabetologia·N van LeeuwenE R Pearson
Aug 3, 2012·Diabetologia·D R MatthewsUNKNOWN Position Statement Writing Group
Oct 31, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·K R Owen
Feb 19, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·A G Jones, A T Hattersley
Sep 21, 2013·Hormone Research in Pædiatrics·Oscar Rubio-Cabezas, Sian Ellard
Citations
Nov 25, 2014·Journal of Internal Medicine·A Emami-RiedmaierM Schwab
Oct 11, 2016·Diabetologia·Leif Groop
Mar 3, 2018·Journal of Diabetes Investigation·Fangying XieRonald Cw Ma
Sep 8, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Peter EibichAlastair M Gray
Jul 17, 2015·Pharmacogenetics and Genomics·Line EngelbrechtsenHenrik Vestergaard