Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer

Clinical Epigenetics
Hege Marie VedeldGuro E Lind

Abstract

We have previously shown that aberrant promoter methylation of ZNF331 is a potential biomarker for colorectal cancer detection with high sensitivity (71%) and specificity (98%). This finding was recently confirmed by others, and it was additionally suggested that promoter methylation of ZNF331 was an independent prognostic biomarker for colorectal cancer (n = 146). In the current study, our initial colorectal cancer sample series was extended to include a total of 423 cancer tissue samples. Aberrant promoter methylation was found in 71% of the samples, thus repeatedly suggesting the biomarker potential of ZNF331 for detection of colorectal cancer. Furthermore, multivariate Cox's analysis indicated a trend towards inferior overall survival for colorectal cancer patients with aberrant methylation of ZNF331.

References

Dec 6, 2005·Nucleic Acids Research·Daniel J WeisenbergerPeter W Laird
Sep 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anita SveenRagnhild A Lothe
Dec 14, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A MerokA Nesbakken
Jun 21, 2014·International Journal of Cancer. Journal International Du Cancer·Hege Marie VedeldGuro E Lind
May 26, 2017·International Journal of Cancer. Journal International Du Cancer·Hege Marie VedeldGuro E Lind
Dec 19, 2017·Seminars in Cancer Biology·Hege Marie VedeldGuro E Lind

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Citations

Mar 26, 2019·Expert Review of Molecular Diagnostics·Lili DuanDaiming Fan
Jun 17, 2020·Expert Review of Proteomics·Margherita BinettiValeria Tonini
Dec 14, 2018·Molecular Diagnosis & Therapy·Katarzyna KamińskaMarzena Anna Lewandowska
Mar 7, 2021·International Journal of Molecular Sciences·Joanna SobocińskaUrszula Oleksiewicz

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Methods Mentioned

BETA
biopsies
surgical resection
PCR

Software Mentioned

R
SPSS Statistics

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