Re-emergence of a fetal pattern of insulin-like growth factor expression during hyperoxic rat lung injury

American Journal of Respiratory Cell and Molecular Biology
K A Veness-MeehanA D Stiles

Abstract

Chronic injury to the developing lung results in cell proliferation and characteristic architectural changes. It is likely that growth factors produced and acting locally are important to these processes. Insulin-like growth factors I and II (IGF-I and IGF-II) are peptide growth factors expressed by lung cells. Roles for IGF-I and IGF-II in lung injury are suggested by their expression during lung development and by studies showing changes in IGF-I expression by activated alveolar macrophages, and increases in IGF-II peptide in oxidant arrested alveolar epithelial cells. To investigate whether the expression of IGF-I and IGF-II are changed with hyperoxic exposure, newborn rats were exposed to 80-90% oxygen for up to 6 wk and Northern hybridization analyses, in situ hybridization histochemistry, immunohistochemical staining, and reverse transcription-polymerase chain reaction (RT-PCR) studies were performed. Northern hybridization analyses of RNA extracted from whole lung showed increases in IGF-I and IGF-II mRNAs with prolonged hyperoxia. In situ hybridization histochemistry and immunohistochemical staining demonstrated spatial patterns of IGF-I and IGF-II expression similar to those seen during fetal lung development. In addit...Continue Reading

Citations

Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Christina LeBedisPnina Brodt
Nov 9, 2004·Pediatric Pulmonology·Esra Arun OzerHasan Ozkan
Jan 19, 1999·Critical Care Clinics·T E Albertson, G P Marelich
Feb 26, 2004·Paediatric Respiratory Reviews·Robert P Jankov, A Keith Tanswell
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S T UhD W Riches
Aug 6, 1998·The Journal of Clinical Investigation·M E SundayR L Emanuel
Apr 9, 2005·Pediatric Research·Jacques BourbonChristophe Delacourt
May 10, 2005·Pediatric Research·Esra A OzerHasan Ozkan
Apr 29, 1998·Experimental Lung Research·W A PriceA D Stiles
Mar 19, 2014·Pediatrics and Neonatology·Özmert M A ÖzdemirÇiğdem Yenisey
Jul 21, 2016·American Journal of Respiratory Cell and Molecular Biology·Miranda SunJ Usha Raj
Aug 29, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·J C ValenciaV J Ferrans
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kathleen A Veness-MeehanAlan D Stiles
Mar 5, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jun LiA Keith Tanswell
Jan 1, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nelida OlaveNamasivayam Ambalavanan
Dec 25, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen K FrankelDavid W H Riches
Nov 12, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alicia MadurgaRory E Morty
Sep 29, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Özmert Ma ÖzdemirHacer Ergin

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