Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014

Transboundary and Emerging Diseases
M A RohaimMuhammad Munir

Abstract

Large-scale surveillance is crucial for understanding the evolution and the emergence of avian influenza viruses (AIVs) in endemic areas. Circulation of highly pathogenic avian influenza (HPAI) subtype H5N1 is continuously causing significant economic losses to the Egyptian poultry industry and is a threat to public health. In this report, a HPAI H5N1 strain (A/chicken/Egypt/Fadllah-7/2014) was detected from a vaccinated flock showing clinical signs of infection. Genetic characterization of the isolate indicated a high level of nucleotide identity (95-98%) with variant and classical groups of H5N1. Moreover, multiple-nucleotide and amino acid alignments revealed several prominent and characteristic substitutions in the surface glycoprotein, which may have biological relevance to the pathobiology of the virus. Phylogenetic analysis demonstrated that the reported isolate closely relates to H5N1 AIVs subclade 2.2.1.1 in spite of no reports of this subclade since 2011 from AI reported cases in Egyptian avian species. In conclusion, our results highlight the re-emergence of a novel H5N1 AIV variant subclade 2.2.1.1 that could escape immunity induced by vaccines. This discovery illustrates the importance of continuous monitoring of p...Continue Reading

References

May 19, 2006·Emerging Infectious Diseases·Gabriele Neumann, Yoshihiro Kawaoka
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Aug 28, 2007·Vaccine·F Carrat, A Flahault
Feb 6, 2008·Archives of Virology·M Haghighat-JahromiA H Shooshtari
Jul 14, 2009·Genomics, Proteomics & Bioinformatics·Venkata R S K DuvvuriJianhong Wu
Apr 20, 2010·Journal of Biomedical Science·Ahmed S Abdel-MoneimSalama A S Shany
Jun 4, 2010·Influenza and Other Respiratory Viruses·Tara AndersonAlex Thiermann
Jun 10, 2011·Virology Journal·Ahmed S Abdel-MoneimMagdy F El-Kady
Nov 23, 2012·Emerging Infectious Diseases·Timothée VergneMarisa Peyre
Mar 25, 2014·Emerging Infectious Diseases·Ghazi KayaliMohamed A Ali
Aug 26, 2014·The World Allergy Organization Journal·Anahí YáñezStephen T Holgate

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