Re-evaluation of histogenesis of gastric carcinomas: a comparative histopathological study between Helicobacter pylori-negative and H. pylori-positive cases.

Digestive Diseases and Sciences
Rie KakinokiTakanori Hattori

Abstract

We histopathologically re-evaluated the histogenesis of gastric carcinomas from comparative studies between Helicobacter pylori-positive and H. pylori-negative cases using the gastritis score from the Updated Sydney System. The incidence of H. pylori-negative gastric carcinomas was 3.11% (12/386); they are likely to develop in the fundic gland mucosa, and show a gastric phenotype by mucin immunohistochemistry. Even in cases of completely gastric and predominantly gastric phenotypes, CDX2 protein was expressed in most cases (90.9% of pT1 and 100% of pT2-3), indicating a possibility that intestinalization of carcinoma cells occurs independently of the background mucosa. Regarding the degree of gastritis of background mucosa surrounding 143 H. pylori-positive differentiated-type adenocarcinomas, the mean score ranged from 1.497 to 1.713. Our data support the hypothesis that intestinal metaplasia is not a precancerous but a paracancerous lesion, and most gastric adenocarcinomas develop in mildly to moderately atrophic mucosa with H. pylori-infection, i.e., ongoing atrophy.

References

Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Oct 17, 1991·The New England Journal of Medicine·A NomuraM J Blaser
Apr 15, 1986·Cancer·T Hattori
Dec 2, 1993·International Journal of Cancer. Journal International Du Cancer·R KushimaT Hattori
Mar 6, 1997·Nature·K ChawengsaksophakF Beck
Aug 1, 1997·Virchows Archiv : an International Journal of Pathology·T YamachikaM Tatematsu
Dec 12, 1997·Gastroenterology·M AsakaM Kato
May 5, 1999·Pathology International·Y EgashiraM Ikegami
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·S TsukashitaT Hattori
Mar 14, 2003·The Journal of Pathology·Hiroshi KawachiMorio Koike
Oct 17, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Minako HirahashiMasazumi Tsuneyoshi

❮ Previous
Next ❯

Citations

Nov 14, 2013·Japanese Journal of Clinical Oncology·Masayoshi YamadaTadakazu Shimoda
Sep 26, 2013·Gastrointestinal Endoscopy·Satoru NonakaYutaka Saito
Apr 10, 2013·Gastrointestinal Endoscopy·Satoru NonakaYutaka Saito
Aug 29, 2009·Helicobacter·Lurdes MonteiroFrancis Mégraud
Nov 9, 2011·Helicobacter·Taiji MatsuoKazuaki Chayama
Mar 18, 2016·Digestive Diseases and Sciences·Toshihisa Takeuchi, Kazuhide Higuchi
Apr 16, 2014·Journal of Gastroenterology and Hepatology·Hee-Won KwakYoung-Woo Kim
Oct 27, 2015·Disease Markers·Hiroshi KishikawaJiro Nishida
Mar 27, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yorimasa YamamotoMasahiro Igarashi
Jul 24, 2013·Seminars in Cancer Biology·Akiko ShiotaniDavid Y Graham
Jan 9, 2015·Clinical Journal of Gastroenterology·Yoshihiko OzakiYasunari Nakamoto
May 3, 2018·Digestion·Akihiro YamadaShu Hoteya
Aug 24, 2018·Current Opinion in Gastroenterology·David Y Graham, Winnie Y Zou
Dec 18, 2009·Expert Review of Anticancer Therapy·Masanori Ito
Apr 9, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Slavica StojnevTakanori Hattori
Nov 17, 2015·Internal Medicine·Tadanobu NagayaOsamu Hasebe
Jul 2, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Q GuoJ Lin
Jul 25, 2018·Disease Models & Mechanisms·Joseph Burclaff, Jason C Mills
Feb 6, 2017·PloS One·Kun-Feng TsaiUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
Jun 12, 2020·World Journal of Gastroenterology : WJG·Chiko SatoShin Maeda
Nov 8, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Toshiaki HirasawaJunko Fujisaki
Apr 17, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Maiko TakitaShin Ichihara
Nov 6, 2021·Journal of Clinical Gastroenterology·Pierfrancesco VisaggiEdoardo Savarino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.