Re-evaluation of pediatric 18 F-FDG dosimetry: Cristy-Eckerman versus UF/NCI hybrid computational phantoms

Physics in Medicine and Biology
Kitiwat KhamwanGeorge Sgouros

Abstract

Because of the concerns associated with radiation exposure at a young age, there is an increased interest in pediatric absorbed dose estimates for imaging agents. Almost all reported pediatric absorbed dose estimates, however, have been determined using adult pharmacokinetic data with radionuclide S values that take into account the anatomical differences between adults and children based upon the older Cristy-Eckerman (C-E) stylized phantoms. In this work, we use pediatric model-derived pharmacokinetics to compare absorbed dose and effective dose estimates for 18F-FDG in pediatric patients using S values generated from two different geometries of computational phantoms. Time-integrated activity coefficients of 18F-FDG in brain, lungs, heart wall, kidneys and liver, retrospectively, calculated from 35 pediatric patients at the Boston's Children Hospital were used. The absorbed dose calculation was performed in accordance with the Medical Internal Radiation Dose method using S values generated from the University of Florida/National Cancer Institute (UF/NCI) hybrid phantoms, as well as those from C-E stylized computational phantoms. The effective dose was computed using tissue-weighting factors from ICRP Publication 60 and ICRP ...Continue Reading

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Citations

Mar 20, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Yu-Mo ZhaoYing-Ying Hu
Jun 3, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jeffrey P SchmallLisa J States

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