Re-evaluation of routine dengue virus serology in travelers in the era of Zika virus emergence

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Maurits P A van MeerCorine H GeurtsvanKessel

Abstract

Diagnostic requests for both Zika virus (ZIKV) and dengue virus (DENV) infections in returning travelers have significantly increased during the recent ZIKV outbreak in the Americás. These flaviviruses have overlapping clinical syndromes and geographical distribution, but diagnostic differentiation is important because of different clinical consequences. As flaviviruses are known to have a short viremic period, diagnostics often rely on serological methods, which are challenging due to extensive cross-reactive antibodies. To re-evaluate the performance of DENV serological assays in laboratory confirmed ZIKV-infected travelers. The extent of cross-reactivity of the DENV NS1 antigen, IgM and IgG ELISA was analyzed in 152 clinical blood samples collected from 69 qRT-PCR and 24 virus neutralization titer (VNT) confirmed ZIKV-infected travelers. The majority of travelers in the presented cohort returned to the Netherlands from Suriname and presented with symptoms of fever and rash. Twenty-three percent of the female travelers were pregnant. None of the 39 ZIKV RNA positive blood samples were cross-reactive in the DENV NS1 antigen ELISA. The rates of cross-reactivity of the DENV IgM and IgG ELISÁs were 31% and 54%, respectively, afte...Continue Reading

Citations

Jan 3, 2018·The Journal of Infectious Diseases·Adriana GoncalvesAnnelies Wilder-Smith
Nov 7, 2017·PLoS Neglected Tropical Diseases·Tereza MagalhaesErnesto T A Marques
Oct 31, 2018·Current Infectious Disease Reports·Annelies Wilder-Smith
Aug 1, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Nader RaafatRichard J Maude
Oct 30, 2019·Acta Microbiologica Et Immunologica Hungarica·Orsolya NagyMária Takács
Mar 17, 2020·Frontiers in Immunology·Abhay P S Rathore, Ashley L St John
Oct 3, 2018·Tropical Medicine and Infectious Disease·Emma J QuinnJillian M Carr
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Jul 11, 2020·Scientific Reports·Alice F VersianiFlávio G da Fonseca
May 16, 2018·Annals of Clinical and Translational Neurology·Corine H GeurtsvanKesselHubert P Endtz
Jun 9, 2018·Current Infectious Disease Reports·Jesus Rodriguez-ManzanoSophie Yacoub
Oct 8, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Chantal ReuskenCorine H GeurtsvanKessel
Oct 25, 2020·Viruses·Claudio SiqueiraJoão Bosco Siqueira
Sep 23, 2021·Journal of the Peripheral Nervous System : JPNS·Sonja E LeonhardBart C Jacobs

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