Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study

Liver International : Official Journal of the International Association for the Study of the Liver
Revital KarivZamir Halpern

Abstract

The upper normal limit (ULN) of serum alanine-aminotrasferase (ALT) normal range was recently challenged, because patients diagnosed with liver diseases may have 'normal' or near-'normal' ALT levels, and because possible modulators are often ignored in determining normal range. To estimate the ULN for serum ALT and to identify factors modulating it. We reviewed medical records of subjects aged 15-90, who underwent standard panels of laboratory tests, including serum ALT, over 6 months at a central laboratory. Three groups were defined: Group 1, comprised total study population (N=272 273). Group 2 (N=87 020) comprised total study population, excluding those receiving potentially hepatotoxic drugs, or diagnosed with liver disease, or had any abnormal laboratory test results other than for triglycerides, cholesterol, glucose, or HbA1c. Group 3 (N=17 496) the 'healthy' population, from whose ALT values we established the new ULN, comprised Group 2 subjects with normal triglycerides, cholesterol, glucose, and HbA1c levels. The 95th percentile ALT values, corresponding to the ULN, in groups 1, 2, and 3 were 50.1, 40, and 37.5 U/l, respectively. 6.2% (16 943/273 273) of subjects whose ALT was below ULN listed by the test manufacturer...Continue Reading

References

Feb 1, 1991·Archives of Internal Medicine·K E Sherman
Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E HayJ Ludwig
Jul 3, 2002·Annals of Internal Medicine·Daniele PratiGirolamo Sirchia
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulio MarchesiniMario Rizzetto
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pouneh MofradArun J Sanyal

❮ Previous
Next ❯

Citations

Jun 26, 2009·European Journal of Clinical Pharmacology·Zhaohui CaiMarianne Keisu
Mar 23, 2010·Hepatology International·Sang Hoon AhnUNKNOWN APPROACH Working Group
Apr 7, 2007·Current Opinion in Gastroenterology·Cherinne Arundel, James H Lewis
Apr 14, 2012·Journal of Gastroenterology and Hepatology·Won SohnHo Soon Choi
Dec 21, 2010·PloS One·Mamie H DongRohit Loomba
Apr 10, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·L PacificoC Chiesa
Apr 11, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Yun HuDa-Wei Gong
Apr 30, 2013·La Revue de médecine interne·D Vital DurandI Durieu
Jul 20, 2010·Clinics in Liver Disease·Michelle Lai, Yun-Fan Liaw
Nov 12, 2009·Regulatory Toxicology and Pharmacology : RTP·Josef S OzerShashi K Ramaiah
May 5, 2009·Metabolism: Clinical and Experimental·Takafumi SaitoSumio Kawata
Oct 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeHillel Tobias
May 6, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Philip S Y TsangMindie H Nguyen
Oct 30, 2014·Journal of Gastroenterology and Hepatology·Narendra S ChoudharyArvinder Singh Soin
Apr 21, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dar-In TaiYun-Fan Liaw
Nov 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David Van der PoortenJacob George
Aug 2, 2008·Alimentary Pharmacology & Therapeutics·N K Gupta, J H Lewis
Oct 13, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Ferruccio CeriottiMauro Panteghini
Oct 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Constance E Ruhl, James E Everhart
Nov 17, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Henry VölzkeMatthias Nauck
Dec 20, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Waka Ohishi, Kazuaki Chayama
Oct 15, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Petra ThulinIna Schuppe-Koistinen
Jul 19, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul MartinIra M Jacobson
Apr 8, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Shira Zelber-SagiGabriel Chodick
Jul 21, 2015·Regulatory Toxicology and Pharmacology : RTP·Heide A Stirnadel-FarrantChristine M Hunt
Jun 24, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Umberto Vespasiani-GentilucciAntonio Picardi
Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Dec 15, 2010·Multiple Sclerosis : Clinical and Laboratory Research·S ChanH Tremlett
Feb 22, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ira M JacobsonKeyur Patel
Apr 22, 2008·The American Journal of Gastroenterology·James FungMan-Fung Yuen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.