Re-examining age-related differences in white matter microstructure with free-water corrected diffusion tensor imaging

Neurobiology of Aging
Jordan A ChadJ Jean Chen

Abstract

Diffusion tensor imaging (DTI) has been used extensively to investigate white matter (WM) microstructural changes during healthy adult aging. However, WM fibers are known to shrink throughout the lifespan, leading to larger interstitial spaces with age. This could allow more extracellular free water molecules to bias DTI metrics, which are relied upon to provide WM microstructural information. Using a cohort of 212 participants, we demonstrate that WM microstructural changes in aging are potentially less pronounced than previously reported once the free water compartment is eliminated. After free water elimination, DTI parameters show age-related differences that match histological evidence of myelin degradation and debris accumulation. The fraction of free water is further shown to associate better with age than any of the conventional DTI parameters. Our findings suggest that DTI analyses involving free water are likely to yield novel insight into retrospective re-analysis of data and to answer new questions in ongoing DTI studies of brain aging.

References

Dec 26, 1992·Annals of the New York Academy of Sciences·W Meier-RugeE Meier
Feb 14, 1998·Neurobiology of Aging·Y TangH J Gundersen
Apr 28, 1999·Journal of Neuropathology and Experimental Neurology·D G DavisW R Markesbery
Oct 12, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P J BasserA Aldroubi
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A L AlexanderD L Parker
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nikos G PapadakisPeter W R Woodruff
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jun 10, 2003·The Journal of Comparative Neurology·Lisbeth MarnerBente Pakkenberg
Sep 23, 2003·Journal of Neurocytology·Alan Peters
Dec 6, 2003·Journal of Neuropathology and Experimental Neurology·D S KnopmanR C Petersen
Dec 9, 2003·Neuron·David S TuchVan J Wedeen
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Dec 13, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel B Ennis, Gordon Kindlmann
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Aug 5, 2006·Neuroscience and Biobehavioral Reviews·Edith V Sullivan, Adolf Pfefferbaum
Sep 4, 2007·Archives of Gerontology and Geriatrics·Bora YoonDong-Won Yang
Dec 14, 2007·Neurobiology of Aging·O PiguetG M Halliday
Jun 24, 2008·Brain : a Journal of Neurology·H NeumannR J M Franklin
Jul 23, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ofer PasternakYaniv Assaf
Aug 29, 2009·NeuroImage·Saad JbabdiStephen M Smith
Nov 3, 2009·NeuroImage·Ofer PasternakPeter J Basser
Dec 15, 2010·Clinical Science·Christian M WestbyChristopher A DeSouza
Jan 26, 2011·NeuroImage·Sjoerd B VosAlexander Leemans
Aug 30, 2011·Biochimica Et Biophysica Acta·David J MaddenAllen W Song
Sep 1, 2011·Journal of Neuroinflammation·Shlomo Rotshenker
Sep 20, 2011·NeuroImage·Claudia Metzler-BaddeleyDerek K Jones
Jan 18, 2012·NeuroImage·Bruce Fischl
Jul 19, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Klaus H Maier-HeinOfer Pasternak
Sep 11, 2014·Annals of Neurology·Benjamin T KressMaiken Nedergaard
Dec 3, 2014·Schizophrenia Research·René C W MandlHilleke E Hulshoff Pol
Oct 21, 2015·NeuroImage·Jesper L R Andersson, Stamatios N Sotiropoulos
Nov 5, 2015·Radiology·Marius de GrootMeike W Vernooij

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Citations

Apr 7, 2019·Neurology·Pauline MaillardCharles DeCarli
Jul 10, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Felix L NägeleChristoph Mulert
Jun 23, 2020·Journal of Alzheimer's Disease : JAD·Maggie RoyMaxime Descoteaux
Oct 22, 2019·Frontiers in Aging Neuroscience·Matthieu DumontUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 28, 2020·Frontiers in Aging Neuroscience·Alexandra M NicaiseStefano Pluchino
Aug 31, 2020·Cerebral Cortex Communications·Kathleen E HupfeldUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 27, 2021·Translational Stroke Research·Peiyu HuangMinming Zhang
May 28, 2021·World Neurosurgery·Amir H FarajiR Mark Richardson
Jun 18, 2021·Brain Communications·Sheelakumari RaghavanPrashanthi Vemuri
Jul 23, 2021·Neuronal Signaling·Eleanor Catherine Sams

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