MHC class I molecules present peptides derived from intracellular proteins, enabling immune surveillance by CD8(+) T cells and the elimination of virus-infected and cancerous cells. It has been argued that the dominant source of MHC class I-presented peptides is through proteasomal degradation of newly synthesized defective proteins, termed defective ribosomal products (DRiPs). Here, we critically examine the DRiP hypothesis and discuss recent studies indicating that antigenic peptides are generated from the entire proteome and not just from failures in protein synthesis or folding.
A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes
Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters
A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes.
An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules
Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins
Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1
Compartmentalized MHC class I antigen processing enhances immunosurveillance by circumventing the law of mass action
Viral and bacterial minigene products are presented by MHC class I molecules with similar efficiencies
Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation
MHC class I antigen processing distinguishes endogenous antigens based on their translation from cellular vs. viral mRNA
Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides
Effects of messenger RNA structure and other translational control mechanisms on major histocompatibility complex-I mediated antigen presentation
Regulation of protein synthesis and autophagy in activated dendritic cells: implications for antigen processing and presentation
The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi
Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction
Ubiquitinated Proteins Isolated From Tumor Cells Are Efficient Substrates for Antigen Cross-Presentation
Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation.
Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules
Low Constitutive Cell Surface Expression of HLA-B Is Caused by a Posttranslational Mechanism Involving Glu180 and Arg239
Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant αβ TCRs Specific for a Conserved Peptide-Qa-1b MHC Class Ib Ligand
Complex antigen presentation pathway for an HLA-A*0201-restricted epitope from Chikungunya 6K protein
Kinetically distinct processing pathways diversify the CD8+ T cell response to a single viral epitope.
Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination.
UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells
Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire.
A Mechanistic Model for Predicting Cell Surface Presentation of Competing Peptides by MHC Class I Molecules
Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation
Binding stability of peptides on major histocompatibility complex class I proteins: role of entropy and dynamics
BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes.
Diverse HLA-I Peptide Repertoires of the APC Lines MUTZ3-Derived Immature and Mature Dendritic Cells and THP1-Derived Macrophages
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