Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles

Alzheimer's Research & Therapy
Sally HunterCambridge City over-75s Cohort Collaboration

Abstract

Alzheimer's disease (AD) is associated with neurofibrillary pathology, including neurofibrillary tangles (NFT), neuritic plaques (NP) and neuropil threads containing aggregated microtubule associated protein tau. Aggregated tau is also associated with granulovacuolar degeneration (GVD). The relationships between tau, GVD, NFT and dementia are unclear. We assessed hippocampal (CA1) tau-immunoreactive GVD and NFT pathology in brain donations from the population-representative Cambridge City over 75s Cohort (CC75C) using the CERAD protocol and a modified protocol that included a morphological characterisation of tau-immunoreactive deposits within neurons as NFTs or as GVD. Associations between GVD, NFT and dementia were investigated. Hippocampal pyramidal neurons affected with either NFT or GVD are common in the older population. Some tau-immunoreactive deposits resemble ghost GVD neurons. Tau immunoreactivity identified GVD in 95% cases rated as none with haematoxylin and eosin staining. Both severe NFT (odds ratio (OR) 7.33, 95% confidence interval (CI) 2.01; 26.80, p = 0.003) and severe GVD (OR 7.48, 95% (CI) 1.54; 36.24, p = 0.012) were associated with dementia status. Increasing NFT (OR 2.47 95% (CI) 1.45; 4.22, p = 0.001) an...Continue Reading

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Citations

Apr 14, 2020·Journal of Alzheimer's Disease : JAD·Sally HunterUNKNOWN Cambridge City over 75s Cohort collaboration
May 31, 2019·Acta Neuropathologica·Yuichi RikuDanielle Seilhean
May 21, 2017·Journal of Alzheimer's Disease : JAD·Sandra L SiedlakXinglong Wang
May 22, 2018·Journal of Alzheimer's Disease : JAD·Sally HunterCarol Brayne
Mar 1, 2018·Physiological Reviews·Michael FrickerGuy C Brown
Sep 5, 2020·Acta Neuropathologica Communications·Vera I WiersmaWiep Scheper

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