Re-examining the Nature and Function of Self-Reactive T cells

Trends in Immunology
David M RichardsMarkus Feuerer

Abstract

Recent studies have leveraged MHC tetramer and TCR sequencing approaches towards a more precise characterization of the peripheral T cell repertoire, providing important insight into both the contribution of self-reactive T cells to the overall repertoire and their function. The peripheral T cell repertoire of healthy individuals contains a high frequency of diverse, self-reactive T cells. Furthermore, self-reactive T cells can perform essential beneficial physiological functions. We review these recent findings here, and discuss their implications to the current understanding of peripheral tolerance and the role of self-reactive T cells in autoimmune disease. We outline gaps in understanding, and argue that an important step forward is to revise the definition of self-reactive T cells to incorporate new concepts regarding the nature and physiological functions of different populations of T cells capable of recognizing self-antigens.

References

Jun 8, 1999·Annual Review of Immunology·H LiR A Mariuzza
Oct 30, 2004·Blood·João P MonteiroAdriana Bonomo
Dec 1, 2006·Nature Immunology·Jeong M KimAlexander Y Rudensky
Apr 12, 2007·Clinical Reviews in Allergy & Immunology·Miri BlankYehuda Shoenfeld
Nov 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Markus FeuererChristophe Benoist
Aug 30, 2008·Nature Clinical Practice. Rheumatology·Keith Elkon, Paolo Casali
Oct 14, 2008·Current Opinion in Immunology·Eric Meffre, Hedda Wardemann
Mar 24, 2009·Annual Review of Immunology·Diane Mathis, Christophe Benoist
Mar 25, 2009·The Journal of Experimental Medicine·Antoine ToulonWendy L Havran
Apr 1, 2009·The Journal of Experimental Medicine·Gabrielle A RizzutoAlan N Houghton
Dec 18, 2009·Nature Immunology·Daniel L Mueller
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Nov 3, 2010·Nature Immunology·Annemieke de JongD Branch Moody
Jan 20, 2011·European Journal of Immunology·Claudia de LallaGiulia Casorati
May 25, 2011·The Journal of Experimental Medicine·Amy E MoranKristin A Hogquist
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·James J MoonMarc K Jenkins
Nov 22, 2011·The Journal of Biological Chemistry·Linda WooldridgeAndrew K Sewell
Dec 14, 2011·Annual Review of Immunology·Gretta L StriteskyKristin A Hogquist
Jan 10, 2012·Annual Review of Immunology·Steven Z JosefowiczAlexander Y Rudensky
Feb 11, 2012·Nature Reviews. Immunology·Chyi-Song HsiehChan-Wang J Lio
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Aug 21, 2012·Nature Reviews. Immunology·Jonathan KipnisNoël C Derecki
Sep 19, 2012·The Journal of Experimental Medicine·Sarah EnouzDietmar Zehn
Oct 17, 2012·The Journal of Experimental Medicine·Justin J TaylorDaniel L Mueller
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gretta L StriteskyKristin A Hogquist
Apr 20, 2013·Brain, Behavior, and Immunity·Kuti Baruch, Michal Schwartz
Jun 4, 2013·The New England Journal of Medicine·Jedd D WolchokMario Sznol
Jan 8, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Michal Schwartz, Catarina Raposo
May 27, 2014·Cell·Michael E BirnbaumK Christopher Garcia
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Byron B Au-YeungArthur Weiss
Aug 20, 2014·Nature Immunology·Kristin A Hogquist, Stephen C Jameson
Sep 19, 2014·European Journal of Immunology·Sofia N NyströmPaul A Gleeson
Nov 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sabrina KoehliEd Palmer

❮ Previous
Next ❯

Citations

Jan 26, 2018·Nature Communications·Bruno RaposoJohan Bäcklund
Jul 11, 2019·Nature Reviews. Rheumatology·Jun DengDi Yu
Apr 5, 2020·Nature Reviews. Clinical Oncology·Khashayar EsfahaniLeonard Calabrese
Nov 23, 2017·Frontiers in Cellular Neuroscience·Silvia Sánchez-Ramón, Florence Faure
Feb 13, 2019·Frontiers in Immunology·Evgeni V NikolaevEduardo D Sontag
Oct 26, 2018·Frontiers in Immunology·Igal Gery, Rachel R Caspi
Feb 18, 2020·British Journal of Haematology·Matthew CormierDavid Lillicrap
Jul 28, 2016·Nature Immunology·Laura CampisiJ Magarian Blander
Aug 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Soyoung A OhMing O Li
Jun 14, 2019·Frontiers in Immunology·Wolf-Henning Boehncke, Nicolo Costantino Brembilla
Oct 28, 2019·Nature Communications·Anna CebulaLeszek Ignatowicz
Aug 11, 2020·Clinical and Translational Allergy·Fariza Mishaal Saiema BadloeInge Kortekaas Krohn
May 10, 2020·Seminars in Radiation Oncology·Raghvendra M SrivastavaTimothy A Chan
Dec 29, 2020·Trends in Pharmacological Sciences·Meredith A Skiba, Andrew C Kruse
Nov 10, 2020·Frontiers in Immunology·Rossana FranzinElena Ranieri
Nov 17, 2020·Frontiers in Pediatrics·Reiner K Mailer
May 13, 2021·Nature Reviews. Clinical Oncology·Laurence ZitvogelGuido Kroemer
May 1, 2021·ELife·Emily N TruckenbrodStephen C Jameson
May 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Qian YinMark M Davis
Jul 3, 2021·International Journal of Molecular Sciences·Ewa KwiatkowskaSebastian Kwiatkowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie
P KourilskyC Jaulin
Current Opinion in Immunology
S C Smith, P M Allen
Critical Reviews in Immunology
Yoichi Maekawa, Koji Yasutomo
© 2022 Meta ULC. All rights reserved