Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack

European Journal of Medicinal Chemistry
Usman Ghani

Abstract

Treatment of diabetes mellitus by oral α-glucosidase inhibitors is currently confined to acarbose, miglitol and voglibose marred by efficacy problems and unwanted side effects. Since the discovery of the drugs more than three decades ago, no significant progress has been made in the drug development area of anti-diabetic α-glucosidase inhibitors. Despite existence of a wide chemical diversity of α-glucosidase inhibitors identified to date, majority of them are simply piled up in publications and reports thus creating a haystack destined to be forgotten in the scientific literature without given consideration for further development into drugs. This review finds those "needles" in that haystack and lays groundwork for highlighting promising α-glucosidase inhibitors from the literature that may potentially become suitable candidates for pre-clinical or clinical trials while drawing attention of the drug development community to consider and take already-identified promising α-glucosidase inhibitors into the next stage of drug development.

References

Sep 1, 1990·British Journal of Clinical Pharmacology·P H JoubertG N Foukaridis
Mar 1, 1987·Diabetes Care·H H FataniA G el-Zubier
Oct 1, 1982·Diabetologia·R A BacchusB Kilshaw
Dec 1, 1994·The Journal of Pharmacy and Pharmacology· Sreejayan, M N Rao
Jan 28, 1993·Nature·M J Berridge
Oct 1, 1996·British Journal of Clinical Pharmacology·J P SelsA C Nieuwenhuijzen Kruseman
Jul 1, 1997·Diabetic Medicine : a Journal of the British Diabetic Association·A R Al-Nuaim
Jun 4, 1998·Journal of Natural Products·N AsanoG W Fleet
Jul 8, 1999·Journal of Natural Products·H KuriharaK Takahashi
May 29, 2000·Organic Letters·S E Denmark, A R Hurd
Feb 24, 2001·Phytochemistry·V PeresF F de Oliveira
Apr 3, 2001·The Journal of Organic Chemistry·A GhavamiB M Pinto
May 2, 2001·Nature Reviews. Molecular Cell Biology·R F Irvine, M J Schell
Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·H J Kloosterboer
Jan 17, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·R M E VosL P C Delbressine
Feb 14, 2002·Diabetes Research and Clinical Practice·Apichati VichayanratPraneet Watanakejorn
Feb 19, 2002·Chemical Reviews·Torgeir Flatmark, Raymond C. Stevens
Jun 28, 2002·Lancet·Jean-Louis ChiassonUNKNOWN STOP-NIDDM Trail Research Group
Sep 1, 2004·Maturitas·Michael J Reed, Helenius J Kloosterboer
May 20, 2005·Glycobiology·Terry D ButtersFrances M Platt
Oct 6, 2005·Bioorganic & Medicinal Chemistry Letters·Woo Duck SeoKi Hun Park
Oct 6, 2005·Bioorganic & Medicinal Chemistry Letters·Byong Won LeeKi Hun Park
Jan 3, 2006·European Journal of Medicinal Chemistry·Zhi-yun DuAlbert S C Chan
Jul 5, 2006·The FEBS Journal·Elena J RossiDavid R Rose
Apr 13, 2007·Bioorganic & Medicinal Chemistry·Hai-Wei XuHong-Min Liu
Oct 24, 2007·Bioorganic & Medicinal Chemistry Letters·Eun Jin SeoKi Hun Park
Jan 15, 2008·Phytochemistry·Atsushi KatoRobert J Nash
Jan 29, 2008·Phytochemistry·Sio-Hong LamShoei-Sheng Lee

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Citations

May 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sunil K SukumaranRobert F Margolskee
Jul 29, 2017·The Journal of Organic Chemistry·Anais Vieira Da CruzSandrine Py
Nov 11, 2017·Chemistry & Biodiversity·Ana P de OliveiraSilvia H Taleb-Contini
Dec 28, 2017·Chemistry : a European Journal·Jean-François NierengartenPhilippe Compain
Oct 8, 2016·Organic & Biomolecular Chemistry·Peng WangMing Li
Aug 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Van Bon NguyenAnh Dzung Nguyen
Oct 12, 2018·Anais Da Academia Brasileira De Ciências·Nguyen Thi LuyenNguyen Tien Dat
Apr 18, 2019·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Philippe Compain
May 31, 2019·Organic & Biomolecular Chemistry·Maëva M PichonPhilippe Compain
May 1, 2019·Medicinal Chemistry·Ioannis Fotopoulos, Dimitra Hadjipavlou-Litina
Aug 24, 2019·Current Diabetes Reviews·Mayukh BanerjeeNarendra Kumar Pandey
Jul 19, 2018·The Journal of Antibiotics·Daniela Rebollar-RamosRachel Mata
Jul 19, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Davut AvcıNecmi Dege
Jul 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Van Bon NguyenNguyen Manh Cuong
Aug 15, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Dulce MoralesAlejandro Zamilpa
Jan 5, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshihiro Natori
Sep 12, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Uday HossainParames C Sil
Feb 9, 2021·Journal of Diabetes and Metabolic Disorders·Vishakha Parab Gaonkar, Kirankumar Hullatti
Jan 23, 2021·RSC Medicinal Chemistry·M I OsellaR L E Furlan
Nov 11, 2020·Pharmaceuticals·Jérémy P SchneiderPhilippe Compain
Jan 18, 2021·International Journal of Biological Macromolecules·Chao JiangChaoyang Ma
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yinan ZhangHua Sun
Mar 16, 2021·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Immo SerbianRené Csuk
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudio ParraHugo Escobar
May 2, 2021·Carbohydrate Research·Mehwish IftikharMin Zhou
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Malose J MphahleleYee Siew Choong
Aug 24, 2021·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Amina M DirirLina F Yousef

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