Re-inforcing the cell death army in the fight against breast cancer

Journal of Cell Science
Clara R L OudenaardenPatrick W B Derksen

Abstract

Metastatic breast cancer is responsible for most breast cancer-related deaths. Disseminated cancer cells have developed an intrinsic ability to resist anchorage-dependent apoptosis (anoikis). Anoikis is caused by the absence of cellular adhesion, a process that underpins lumen formation and maintenance during mammary gland development and homeostasis. In healthy cells, anoikis is mostly governed by B-cell lymphoma-2 (BCL2) protein family members. Metastatic cancer cells, however, have often developed autocrine BCL2-dependent resistance mechanisms to counteract anoikis. In this Review, we discuss how a pro-apoptotic subgroup of the BCL2 protein family, known as the BH3-only proteins, controls apoptosis and anoikis during mammary gland homeostasis and to what extent their inhibition confers tumor suppressive functions in metastatic breast cancer. Specifically, the role of the two pro-apoptotic BH3-only proteins BCL2-modifying factor (BMF) and BCL2-interacting mediator of cell death (BIM) will be discussed here. We assess current developments in treatment that focus on mimicking the function of the BH3-only proteins to induce apoptosis, and consider their applicability to restore normal apoptotic responses in anchorage-independent...Continue Reading

References

Feb 1, 1994·The Journal of Cell Biology·S M Frisch, H Francis
Sep 1, 1993·Molecular Biology of the Cell·J E MeredithM A Schwartz
May 1, 1996·Mechanisms of Development·K HeermeierL Hennighausen
Feb 28, 1998·The EMBO Journal·L O'ConnorD C Huang
Sep 12, 1998·Science·J M Adams, S Cory
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 25, 2000·Endocrine-related Cancer·S KrajewskiJ C Reed
Apr 7, 2000·Breast Cancer Research and Treatment·P M FernandezS R Patierno
Jan 1, 1996·Journal of Mammary Gland Biology and Neoplasia·D Medina
Feb 13, 2001·Microscopy Research and Technique·R StrangeM Dang
Feb 15, 2001·Endocrine-related Cancer·R KumarL Adam
Feb 15, 2001·Nature Cell Biology·S P TzungD M Hockenbery
Mar 16, 2001·Breast Cancer Research : BCR·N E Hynes
Nov 8, 2001·Experimental Cell Research·R R SubramanianH Fu
Dec 26, 2001·Human Mutation·Gloria H SuScott E Kern
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie StahlRené H Medema
Jun 11, 2002·Human Pathology·Shikha BoseRamon Parsons
Aug 10, 2002·Wiener medizinische Wochenschrift·P VaupelM Höckel
Jul 5, 2003·Nature Cell Biology·Mauricio J ReginatoJoan S Brugge
Dec 3, 2003·The Journal of Biological Chemistry·Han C DanJin Q Cheng
Mar 5, 2004·Biochimica Et Biophysica Acta·Andrew M PetrosStephen W Fesik
Jul 13, 2004·Biochimica Et Biophysica Acta·Stuart S Martin, Kristiina Vuori
Dec 14, 2004·Cell Death and Differentiation·M AdachiK Imai
May 19, 2005·Molecular and Cellular Biology·Mauricio J ReginatoJoan S Brugge
May 20, 2005·Nature·Tilman OltersdorfSaul H Rosenberg
Jun 11, 2005·Cell Death and Differentiation·R LeyS J Cook
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tobias SchmelzleJoan S Brugge
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ramzi M MohammadAyad Al-Katib
Oct 24, 2007·Cellular and Molecular Life Sciences : CMLS·F LaniganW M Gallagher
Nov 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mai NguyenGordon C Shore

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Sep 28, 2021·Frontiers in Cell and Developmental Biology·Albert Manzano-MuñozJoan Montero

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