Re-treatment of chronic hepatitis C with consensus interferon

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
E J HeathcoteL Blatt

Abstract

A multicenter, open-label, phase 3 study was conducted in 337 patients with chronic hepatitis C virus (HCV) infection who had either not responded to previous interferon therapy or had relapsed after discontinuation of therapy with either consensus interferon (9 microg) or interferon alpha-2b (3 million U) three times a week for 24 weeks. Patients were randomized to receive a higher dose of consensus interferon (15 microg) administered subcutaneously three times a week for 24 or 48 weeks and then were observed for an additional 24 weeks. Patients who had relapsed after prior interferon therapy were more likely to have a sustained alanine aminotransferase response and HCV RNA response (as measured by reverse transcription-polymerase chain reaction with a sensitivity of < 100 copies/mL) than were patients who had not responded to prior interferon therapy. For relapsers, the sustained HCV RNA response rate was 58% (48 weeks) and 28% (24 weeks). The sustained alanine aminotransferase response for relapsers was 52% (48 weeks) and 39% (24 weeks). The sustained HCV RNA response rate among prior nonresponders was 13% (48 weeks) and 5% (24 weeks), and the sustained alanine aminotransferase response rate for nonresponders was 17% (48 wee...Continue Reading

References

Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ShindoJ H Hoofnagle
Nov 1, 1992·The Journal of Infectious Diseases·E MarriottV Carreño
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Q L ChooP J Barr
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N OgataR H Purcell
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Di BisceglieH J Alter
Nov 7, 1990·JAMA : the Journal of the American Medical Association·M J AlterD W Bradley
Jan 1, 1987·Annual Review of Biochemistry·S PestkaC E Samuel
Nov 30, 1989·The New England Journal of Medicine·G L DavisUNKNOWN Hepatitis Interventional Therapy Group
Nov 1, 1989·Seminars in Liver Disease·P F Renault, J H Hoofnagle
Feb 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·T Vial, J Descotes
Feb 1, 1995·Seminars in Liver Disease·M W Fried, J H Hoofnagle
Jun 1, 1995·The New England Journal of Medicine·M J TongR L Co
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P SimmondsD S Chen
Mar 1, 1993·The Journal of Infectious Diseases·P MarcellinJ P Benhamou
Jul 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L M BlattM W Taylor
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J TongJ Lubina

❮ Previous
Next ❯

Citations

Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W M LeeS Gardner
Apr 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J W FangJ Y Lau
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J HeathcoteD G Albert
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K R ReddyT Joh
Sep 12, 2000·Current Gastroenterology Reports·P Y Kwo
Jan 18, 2003·Current Gastroenterology Reports·Todd E Dantzler, Eric J Lawitz
Mar 3, 2006·Current Gastroenterology Reports·Mitchell L Shiffman
Sep 12, 2000·Current Gastroenterology Reports·G L Davis
Nov 30, 2000·Current Treatment Options in Gastroenterology·M A Costa, E R Schiff
Feb 1, 2000·The American Journal of Medicine·B R Bacon
Jan 6, 2000·Journal of Hepatology·S W SchalmT G van Rossum
Oct 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B Keeffe
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A KornbergJ Scheele
Mar 22, 2001·Journal of Internal Medicine·A M Larson, R L Carithers
Oct 31, 1998·Journal of Viral Hepatitis·G M Dusheiko
Oct 31, 1998·Journal of Viral Hepatitis·J Heathcote
Jun 10, 2000·Journal of Viral Hepatitis·L A KondiliA Mele
Feb 1, 2003·Journal of Viral Hepatitis·S J CotlerD M Jensen
Aug 2, 2000·Journal of Gastroenterology and Hepatology·S Pianko, J G McHutchison
Aug 2, 2000·Journal of Gastroenterology and Hepatology·W C Chow
Feb 24, 2001·Journal of Gastroenterology and Hepatology·J H KaoD S Chen
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G T Everson
Nov 20, 1998·The New England Journal of Medicine·T J Liang
Jan 19, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S J CotlerM W Taylor
Jun 15, 2001·ILAR Journal·D B Strader, L B Seeff
Oct 7, 2006·Current Opinion in Gastroenterology·A Regev, E R Schiff
Dec 9, 2000·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·A BirkelL Benson
Mar 20, 1999·Current Opinion in Pediatrics·D M Zerr, L M Frenkel
Feb 24, 2001·Australian and New Zealand Journal of Medicine·G W McCaughan, S I Strasser
Apr 13, 2005·Nephron. Clinical Practice·Serkan KahramanCetin Turgan
Jan 17, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Shuhei Yasuda, Keiji Miyata
Aug 27, 2009·Biologics : Targets & Therapy·Th Witthöft
Aug 27, 2009·Therapeutics and Clinical Risk Management·Wikrom KarnsakulKathleen B Schwarz
Mar 26, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Milomir Dokić, Vesna Begović
Sep 15, 2011·Immunotherapy·Aarthi Chary, Mark Holodniy
Aug 5, 2011·Gut and Liver·Jae Young Jang, Raymond T Chung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
W C ChowP Marcellin
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
L BlattM W Taylor
Liver International : Official Journal of the International Association for the Study of the Liver
Wulf O BöcherPeter R Galle
© 2022 Meta ULC. All rights reserved