Re-treatment with interferon alfa of patients with chronic hepatitis C

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
W C ChowP Marcellin

Abstract

Treatment of patients with chronic hepatitis C has had limited success because of relapses and nonresponse to interferon alfa therapy (currently the only established therapeutic agent). A retrospective study was done to determine the efficacy of re-treatment with interferon and the predictors of response in patients who failed to achieve sustained response after one standard course of interferon therapy (3 million units three times a week for 24 weeks). One hundred and eleven patients (47 relapsers and 64 nonresponders), mean age 45 years, were included in the study. Eighteen relapsers and 13 nonresponders received a higher dose (5 MU), and 11 relapsers and 6 nonresponders received a longer duration (48 weeks) of interferon therapy. The remaining patients received the same regimen as the first treatment. Eighty-one percent and 23% of relapsers and nonresponders, respectively, had an end-of-treatment response, and 19% and 3% of the corresponding patient groups had a sustained response to re-treatment. Two patients with breakthrough during their first treatment were the only nonresponders with sustained response after re-treatment. Sustained response was observed only in patients who received an increased dose or duration of inte...Continue Reading

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Citations

Sep 12, 2000·Current Gastroenterology Reports·P Y Kwo
Jan 6, 2000·Journal of Hepatology·M Buti, R Esteban
Mar 20, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P N ChengT T Chang
Jan 25, 2013·Nature Reviews. Cancer·Alla ArzumanyanMark A Feitelson
Jun 10, 2000·Journal of Viral Hepatitis·L A KondiliA Mele
Aug 2, 2000·Journal of Gastroenterology and Hepatology·W C Chow
Oct 7, 2006·Current Opinion in Gastroenterology·A Regev, E R Schiff
Dec 29, 2000·Journal of Clinical Gastroenterology·K IyodaM Masuzawa
Mar 23, 2000·Journal of Hepatology·N Boyer, P Marcellin
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C CammàA Craxì
Mar 11, 2006·Infectious Disease Clinics of North America·Furqaan Ahmed, Ira M Jacobson
Dec 20, 2007·Journal of Viral Hepatitis·M Deutsch, S J Hadziyannis
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Aug 25, 2004·Gastroenterology Clinics of North America·Furqaan Ahmed, Ira M Jacobson
Jul 3, 2004·Journal of Viral Hepatitis·G V Papatheodoridis, E Cholongitas

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