Reaching and Grasping Training Improves Functional Recovery After Chronic Cervical Spinal Cord Injury

Frontiers in Cellular Neuroscience
Chrystine GallegosQi Lin Cao

Abstract

Previous studies suggest locomotion training could be an effective non-invasive therapy after spinal cord injury (SCI) using primarily acute thoracic injuries. However, the majority of SCI patients have chronic cervical injuries. Regaining hand function could significantly increase their quality of life. In this study, we used a clinically relevant chronic cervical contusion to study the therapeutic efficacy of rehabilitation in forelimb functional recovery. Nude rats received a moderate C5 unilateral contusive injury and were then divided into two groups with or without Modified Montoya Staircase (MMS) rehabilitation. For the rehabilitation group, rats were trained 5 days a week starting at 8 weeks post-injury (PI) for 6 weeks. All rats were assessed for skilled forelimb functions with MMS test weekly and for untrained gross forelimb locomotion with grooming and horizontal ladder (HL) tests biweekly. Our results showed that MMS rehabilitation significantly increased the number of pellets taken at 13 and 14 weeks PI and the accuracy rates at 12 to 14 weeks PI. However, there were no significant differences in the grooming scores or the percentage of HL missteps at any time point. Histological analyses revealed that MMS rehabili...Continue Reading

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Citations

Jun 3, 2021·International Journal of Molecular Sciences·Jadwiga N BilchakMarie-Pascale Côté
Nov 24, 2021·Experimental Neurology·Olaia Baylo-MarínGuillermo García-Alías

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