PMID: 6976805Dec 1, 1981Paper

Reaction between syngeneic hematopoietic stem cells and lymphocytes in leukemic AKR mice

Biulleten' eksperimental'noĭ biologii i meditsiny
Iu I chekanova, L V Riabova

Abstract

The syngeneic donor-recipient model was used to examine the influence of T lymphocytes from AKR mice with spontaneous leukemia on colony-formation and differentiation of hemopoietic stem cells. It was shown that in the stage of the neoplastic process development, the cells of lymph nodes and the thymus inhibited the colony-forming capacity in all the three hemopoietic lines (erythroid, myeloid, megakaryocytic) of the syngeneic normal and autologous bone marrow. In the late stages of leukemia aggravated by generalized infection, T lymphocytes stimulated the exo- and endogenous growth of the granuloid colonies, changing the erythroid-myeloid index to 1:1-1:2.7.

References

Jul 24, 1975·The Journal of Membrane Biology·P M BhargavaF Zajdela

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