Reaction-diffusion degradation model for delayed erosion of cross-linked polyanhydride biomaterials

Physical Chemistry Chemical Physics : PCCP
Sergii DomanskyiVladimir Privman

Abstract

We develop a theoretical model to explain the long induction interval of water intake that precedes the onset of erosion due to degradation caused by hydrolysis in the recently synthesized and studied cross-linked polyanhydrides. Various kinetic mechanisms are incorporated in the model in an attempt to explain the experimental data for the mass loss profile. Our key finding is that the observed long induction interval is attributable to the nonlinear dependence of the degradation rate constants on the local water concentration, which essentially amounts to the breakdown of the standard rate-equation approach, potential causes for which are then discussed. Our theoretical results offer physical insights into which microscopic studies will be required to supplement the presently available macroscopic mass-loss data in order to fully understand the origin of the observed behavior.

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Citations

Dec 23, 2015·Physical Chemistry Chemical Physics : PCCP·Queeny DasguptaGiridhar Madras
Mar 26, 2016·Journal of Biomedical Materials Research. Part a·Halimatu S MohammedDevon A Shipp
Mar 25, 2020·Macromolecular Bioscience·Brittany L SnyderDevon A Shipp
May 1, 2018·Advanced Materials·Arijit Basu, Abraham J Domb
Apr 19, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Lina BianPaul J G Goulet

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