Reaction-diffusion-delay model for EPO/TNF-α interaction in articular cartilage lesion abatement.

Biology Direct
Jason M GrahamJames A Martin

Abstract

Injuries to articular cartilage result in the development of lesions that form on the surface of the cartilage. Such lesions are associated with articular cartilage degeneration and osteoarthritis. The typical injury response often causes collateral damage, primarily an effect of inflammation, which results in the spread of lesions beyond the region where the initial injury occurs. We present a minimal mathematical model based on known mechanisms to investigate the spread and abatement of such lesions. The first case corresponds to the parameter values listed in Table 1, while the second case has parameter values as in Table 2. In particular we represent the "balancing act" between pro-inflammatory and anti-inflammatory cytokines that is hypothesized to be a principal mechanism in the expansion properties of cartilage damage during the typical injury response. We present preliminary results of in vitro studies that confirm the anti-inflammatory activities of the cytokine erythropoietin (EPO). We assume that the diffusion of cytokines determine the spatial behavior of injury response and lesion expansion so that a reaction diffusion system involving chemical species and chondrocyte cell state population densities is a natural wa...Continue Reading

References

Sep 16, 2003·Annals of Biomedical Engineering·Holly A Leddy, Farshid Guilak
Jul 22, 2006·EMBO Reports·Helena Erlandsson Harris, Angela Raucci
Oct 13, 2006·Journal of Leukocyte Biology·Marco E Bianchi
May 7, 2008·Current Rheumatology Reports·Marcello Del Carlo, Richard F Loeser
Jan 9, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Prem RamakrishnanJames A Martin
Jan 29, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wendy GoodwinJames A Martin

❮ Previous
Next ❯

Citations

Sep 25, 2012·Cell Biochemistry and Function·Luisa GenneroRocco De Siena
Apr 23, 2014·International Journal for Numerical Methods in Biomedical Engineering·Xiayi WangJames A Martin
Mar 26, 2015·Frontiers in Bioengineering and Biotechnology·Xiayi WangJames A Martin
Sep 23, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bruce P AyatiJames A Martin
Feb 18, 2017·IEEE Journal of Biomedical and Health Informatics·Israr Bin M IbrahimRamana M Pidaparti
Aug 11, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·James A MartinJoseph A Buckwalter
Feb 19, 2017·Journal of Mathematical Biology·Michelle BakerMarkus R Owen
Nov 16, 2016·Frontiers in Bioengineering and Biotechnology·Georgi I KapitanovJames A Martin

❮ Previous
Next ❯

Software Mentioned

MATLAB
dde23

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

© 2022 Meta ULC. All rights reserved