Reaction discovery using acetylene gas as the chemical feedstock accelerated by the "stop-flow" micro-tubing reactor system

Chemical Science
Fei XueJie Wu

Abstract

Acetylene gas has been applied as a feedstock under transition-metal catalysis and photo-redox conditions to produce important chemicals including terminal alkynes, fulvenes, and fluorinated styrene compounds. The reaction discovery process was accelerated through the use of "stop-flow" micro-tubing reactors. This reactor prototype was developed by joining elements from both continuous micro-flow and conventional batch reactors, which was convenient and effective for gas/liquid reaction screening. Notably, the developed transformations were either inefficient or unsuccessful in conventional batch reactors. Its success relies on the unique advantages provided by this "stop-flow" micro-tubing reactor system.

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Sep 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir V VoroninValentine P Ananikov
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