Reaction of arynes with amino acid esters

Chemical Communications : Chem Comm
Kentaro OkumaYoshinobu Yokomori


An efficient route to a variety of 2-phenylindolin-3-ones from amino acid methyl esters has been developed. The reaction of amino acid methyl esters with benzyne prepared from 2-(trimethylsilyl)phenyl triflate and CsF gave 2-phenylindolin-3-ones in moderate to good yields.


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