Reaction of human alveolar macrophages to exposure to Aspergillus fumigatus and inert particles

Environmental Research
K NessaP Camner

Abstract

In vitro interaction of human alveolar macrophages (AM) with heat-killed conidia from Aspergillus fumigatus and inert silica particles of similar size, about 3 microns, was studied. The conidia were phagocytized significantly faster by AM than were the control particles partly due to the faster rate of attachment but especially due to the faster rate of ingestion. Quantitative nitroblue tetrazolium (NBT) reduction by AM, reflecting their release of oxygen radicals, was increased by a factor of 2 to 3 in response to the conidia during phagocytosis. The silica particles induced a moderate but significant increase in NBT reduction. Conidia, but not silica particles, showed a considerable percentage (around 8%) of phagolysosomes with neutral pH after 3 h and a smaller percentage (around 1%) after 24 h of incubation. The pH of phagolysosomes with conidia tended to be higher after 3 h, but was significantly lower after 24 h than the pH of phagolysosomes with silica particles. Despite the markedly increased oxidative metabolism there was no increase in cytokine production [interleukins (IL) 6 and 8 and tumor necrosis factor alpha (TNF-alpha)] after exposure to conidia. The silica particles induced a significant decrease in IL-6 and IL...Continue Reading

References

Jan 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G Y MinamotoN J Vander Els
Mar 7, 1991·The New England Journal of Medicine·D W DenningD A Stevens
Mar 1, 1991·The American Review of Respiratory Disease·R E DalesH Zwanenburg
Jul 1, 1989·Experimental Lung Research·K NybergP Camner
Nov 1, 1989·The American Review of Respiratory Disease·B BrunekreefB G Ferris
Jul 1, 1988·The American Review of Respiratory Disease·G P BrownG W Hunninghake
Mar 1, 1984·The Journal of Clinical Investigation·B M Babior
Aug 1, 1983·The Journal of Infectious Diseases·T L GustafsonR H Hutcheson
Jan 1, 1996·Experimental Lung Research·K PhilipsonP Camner

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Citations

Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Stephanie C Tucker, Arturo Casadevall
Feb 8, 2018·The Journal of Biological Chemistry·Sarah Sze Wah WongVishukumar Aimanianda
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K BleaseC M Hogaboam
May 17, 2002·Journal of Applied Physiology·Per CamnerConnie Jarstrand
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·E Jean CornishJames B Burritt
Apr 9, 1999·Clinical Microbiology Reviews·J P Latgé

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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