PMID: 9214572Jan 1, 1997Paper

Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigations

Free Radical Biology & Medicine
Z MatuszakC F Chignell

Abstract

It has been suggested that the indole hormone melatonin (N-acetyl-5-methoxytryptamine, MLT) is an important natural antioxidant and free radical scavenger [J. Pineal Res., 14:51; 1993]. In the present work we determined the rate constants, k(r), for scavenging .OH radicals by melatonin, 5-methoxytryptamine (5-MeO-T), 5-hydroxytryptamine (serotonin, 5-OH-T), 6-chloromelatonin (6-Cl-MLT), 6-hydroxymelatonin (6-OH-MLT), and kynurenine (KN) in aqueous solutions. Hydroxyl radicals were generated using a Fenton reaction in the presence of the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO), which competed with the indoles for the radicals. It was found that MLT reacts with .OH with k(r) = 2.7 x 10(10) M(-1) s(-1). Other indoles and KN reacted with .OH radicals with similarly high rates (k(r) > 10(10) M(-1) s(-1)). In contrast to nonhydroxylated indoles (MLT, 6-Cl-MLT, and 5-MeO-T), hydroxylated indoles (5-OH-T and 6-OH-MLT) may function both as .OH promoters and .OH scavengers. The melatonin precursor serotonin promoted the generation of .OH radicals in the presence of ferric iron and H2O2, and the melatonin metabolite 6-hydroxymelatonin generated large quantities of .OH radicals in aerated solutions containing Fe3+ ion, even in th...Continue Reading

References

Apr 29, 1980·Biochemical and Biophysical Research Communications·T UemuraT Yamano
Dec 29, 1980·FEBS Letters·T UemuraT Yamano
May 31, 1994·Annals of the New York Academy of Sciences·R J ReiterS Saarela
May 1, 1993·Journal of Pineal Research·B PoeggelerL C Manchester
May 1, 1995·Journal of Pineal Research·C M CagnoliH Manev
Jan 1, 1996·Free Radical Biology & Medicine·K A MarshallB Halliwell

❮ Previous
Next ❯

Citations

Nov 4, 2000·Journal of Biomedical Science·R J ReiterE Gitto
May 30, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A K AmstrupL Rejnmark
Sep 11, 2007·Bioscience Reports·Deepa S MaharajSanty Daya
Jul 21, 2011·Journal of Mammary Gland Biology and Neoplasia·Steven M HillTamika Duplesis
Nov 24, 1998·Biochemical Pharmacology·C E BeyerD Saphier
Mar 20, 1999·Mutation Research· VijayalaxmiK S Kumar
Dec 18, 2002·Bioorganic Chemistry·Joseph A HorstmanGlenn Dryhurst
Jun 5, 2002·Mechanisms of Ageing and Development·Russel J ReiterSusanne Burkhardt
Nov 27, 1999·Mechanisms of Ageing and Development·R J ReiterV Rouvier-Garay
Oct 14, 1998·Progress in Neurobiology·R J Reiter
Jun 28, 2003·Biochimica Et Biophysica Acta·Kentaro KogureHiroshi Terada
Jul 4, 1998·Toxicology Letters·D MelchiorriG Nisticò
Nov 6, 2003·Journal of Chemical Neuroanatomy·Deepa S MaharajSanty Daya
Apr 16, 1998·Journal of Photochemistry and Photobiology. B, Biology·J E RobertsJ F Wishart
Aug 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M SariahmetogluA Townshend
Jun 26, 2003·European Journal of Biochemistry·Lars F OlsenUrsula Kummer
Sep 21, 2000·Proceedings of the Society for Experimental Biology and Medicine·M Karbownik, R J Reiter
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R D Soloway, S A Weinman
Nov 7, 2008·Clinical and Experimental Pharmacology & Physiology·Ahmed M MohamadinAshraf B Abdel-Naim
Mar 24, 1998·Journal of Pineal Research·R PähklaL Rägo
Sep 24, 1998·Journal of Pineal Research·Y OkataniY Sagara
Sep 25, 1999·Journal of Pineal Research·Y OkataniK Watanabe
Oct 27, 1999·Journal of Pineal Research·Y NodaL Packer
Dec 25, 2004·Journal of Pineal Research·Christian Keithahn, Alexander Lerchl
Feb 3, 1999·Annals of the New York Academy of Sciences·R J ReiterD Acuña-Castroviejo
Feb 11, 2000·Annals of the New York Academy of Sciences·S D SkaperP Giusti
Jun 14, 2003·Redox Report : Communications in Free Radical Research·Dominique Bonnefont-RousselotMonique Gardès-Albert
Feb 6, 2004·Chemical & Pharmaceutical Bulletin·Shinji AbeToshiaki Tamaki
Sep 1, 2008·Interdisciplinary Toxicology·Russel J ReiterDun-Xian Tan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved