Reaction of vaginal tissue of rabbits to inserted sponges made of various materials

Journal of Biomedical Materials Research
M ChvapilC Eskelson

Abstract

Sponges of the same size made of collagen (CS), polyurethane (PU), polyvinylalcohol (PVA) and acetylcellulose (AC) were inserted for 10 days in the vaginas of 22 rabbits. Light and scanning electron microscopy of the vaginal wall and its mucosal lining showed signs of cytotoxicity only with PU and AC while CS and PVA picture did not differ from sham controls. In order to explain the reasons for the toxic effects, all sponges were extracted into aqueous or organic solvent media and analyzed by gas liquid chromatography. Only several minute peaks in organic solvents were found. Extracts of all sponges tested for cytotoxicity in fibroblast cultures showed significant inhibition of H3-thymidine uptake. Nevertheless, extract of collagen sponge was significantly less cytotoxic than the extracts of all other sponges.

References

Mar 1, 1978·Biomedical Mass Spectrometry·C D EskelsonT Chvapil
Sep 1, 1977·Journal of Biomedical Materials Research·M Chvapil
Jan 1, 1974·Acta Endocrinologica. Supplementum·R G McConnell
May 1, 1974·The Journal of Surgical Research·R E ClarkJ F Moran
Oct 1, 1969·Journal of Reproduction and Fertility·P EcksteinA J Sobrero

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Citations

Jul 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W C ThomasR F McConnell
Dec 31, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C C DeMerlis, D R Schoneker
Nov 9, 2011·Antimicrobial Agents and Chemotherapy·José A Fernández-RomeroThomas M Zydowsky
Apr 18, 2014·PloS One·Larisa KizimaJosé A Fernández-Romero
Aug 31, 2002·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·G CreatsasP Colin
May 1, 1982·Journal of Biomedical Materials Research·M Chvapil

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