PMID: 38953Jun 6, 1978

Reaction rates of superoxide radicals with the essential amino acids

Ciba Foundation Symposium
B H Bielski, G G Shiue

Abstract

Upper limits for the rates of reaction of amino acids with superoxide radicals have been determined spectrophotometrically by the stopped flow method. Rate measurements at 23 degrees C for the reaction of HO2 with amino acids were made in the pH range between 1 and 2; similar measurements for O2- were taken near pH 10. The results show that, overall, amino acids are relatively unreactive toward both HO2 and O2-. Computed second-order rate constants for their interaction with HO2 range from 101 mol-1s-1 for aliphatic amino acids to about 600 1 mol-1s-1. The second-order rate constants for the interaction of amino acids with O2- are smaller and range from 0.1 to about 20 1 mol-1s-1.

References

Sep 1, 1981·Critical Reviews in Toxicology·T Akino, K Ohno
Jan 1, 1993·Journal of Toxicology. Clinical Toxicology·J A Brent, B H Rumack
Oct 16, 2013·Antioxidants & Redox Signaling·Beate Fuchs, Jürgen Schiller
Jan 1, 1991·Free Radical Research Communications·W BorsM Saran

Related Concepts

Dioxygen
Amino Acids, I.V. solution additive
Free Radicals
Radicals (chemistry)
Superoxides
Amino Acids, Essential
Hydrogen-Ion Concentration
Cysteine Hydrochloride
Antifibrinolytic amino acids

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