Reactions of antimicrobial species to imidazole-microwave plasma reacted poly(dimethylsiloxane) surfaces

Langmuir : the ACS Journal of Surfaces and Colloids
Woo-Sung Bae, Marek W Urban

Abstract

Microwave plasma reactions of imidazole, 2-methylimidazole, and 2-ethylimidazole on poly(dimethylsiloxane) (PDMS) surfaces resulted in the formation of species containing conjugated surface domains which can be utilized for further reactions. When imidazole and its derivatives were used, polymerization of imidazole and the formation of C=C and CN conjugated species occurred. However, the extent of reactions for each monomer depends on not only the reaction time but also the molecular structure. For methyl- and ethyl-substituted imidazole, more stable radical species are generated and sustain their excited state in the high-energy plasma environments. Specifically, dehydrogenated 2-methyl, 2-ethylimidazole radicals and (*)N=CR-NH(*) (R = -CH(3), -CH(2)CH(3)) species exhibit higher stability than dehydrogenated imidazole radicals and (*)N=CH-NH(*) species under plasma reaction conditions. Such prepared surfaces are capable of attaching antimicrobial drugs via the Pinner synthesis. These studies show that it is possible to react antimicrobial species such as chloramphenicol, and this promising approach offers numerous applications of microwave plasma reactions in biotechnology. Quantitative analysis of the depth of surface reactio...Continue Reading

Citations

Apr 2, 2010·Microfluidics and Nanofluidics·Ieong Wong, Chih-Ming Ho
Apr 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Heather A Pearson, Marek W Urban
Feb 13, 2007·Biomacromolecules·Nattharika AumsuwanMarek W Urban

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