PMID: 9138Sep 13, 1976

Reactions of the ferri-ferrocytochrome-c system with superoxide/oxygen and CO2-/CO2 studied by fast pulse radiolysis

Biochimica Et Biophysica Acta
H SekiG Stein

Abstract

The reduction of ferricytochrome c by O2- and CO2- was studied in the pH range 6.6-9.2 and Arrhenius as well as Eyring parameters were derived from the rate constants and their temperature dependence. Ionic effects on the rate indicate that the redox process proceeds through a multiply-positively charged interaction site on cytochrome c. It is shown that the reaction with O2- (and correspondingly with O2 of ferrocytochrome c) is by a factor of approx. 10(3) slower than warranted by factors such as redox potential. Evidence is adduced to support the view that this slowness is connected with the role of water in the interaction between O2-/O2 and ferri-ferrocytochrome c in the positively charged interaction site on cytochrome c in which water molecules are specifically involved in maintaining the local structure of cytochrome c and participate in the process of electron equivalent transfer.

References

May 6, 1975·Biochemistry·R H Cassell, I Fridovich
Feb 22, 1973·Biochimica Et Biophysica Acta·T Kihara, J A McCray
Feb 1, 1974·Science·A Shafferman, G Stein
May 15, 1974·Journal of the American Chemical Society·H L HodgesH B Gray
Aug 15, 1974·FEBS Letters·P Muir Wood
Jul 1, 1971·Archives of Biochemistry and Biophysics·E J Land, A J Swallow
Feb 2, 1971·Biochemistry·L S. KaminskyA J. Davison
Nov 15, 1971·FEBS Letters·A J. DavisonL S. Kaminsky

Related Concepts

Carbon Dioxide
Cytochrome c Group
Free Radicals
Hydrogen-Ion Concentration
Mathematics
Osmolality
Dioxygen
Plasma Protein Binding Capacity
Superoxides

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