PMID: 6406125Jun 1, 1983Paper

Reactions of thigh tissues of sheep to blunt trauma

Clinical Orthopaedics and Related Research
M Walton, A G Rothwell

Abstract

Severe damage to the deep musculature of the thigh was caused by standardized crushing injuries applied to muscle overlying the femora of anesthetized sheep. The injuries caused an acute inflammatory response, with the formation of granulation tissue and, later, extensive scarring. Periosteal bone formed in all cases, in some instances resulting in a spike of bone that protruded into the overlying soft tissue. Heterotopic bone formed in 16.6% of the legs of sheep within three weeks to three months after trauma by intramembranous ossification within scar tissue replacing muscle tissue.

Citations

Dec 11, 2007·Journal of Science and Medicine in Sport·Con Hrysomallis
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May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth LeblancGuillaume Grenier
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