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Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial

JAMA Neurology

Nov 11, 2019

Richard M TsaiAdam L. Boxer

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Abstract

Basket-design clinical trials that allow investigation of treatment effects on different clinical syndromes that share the same molecular pathophysiology have not previously been attempted in neurodegenerative disease. To assess the safety, tolerability, and pharmacodynamics of the micr...read more

Mentioned in this Paper

Alzheimer's Disease
Biological Markers
Cerebrospinal Fluid
Clinical Trials
Double-Blind Method
Male Population Group
Microtubules
Nerve Degeneration
Neuropsychology
Positron-Emission Tomography
19
1
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Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial

JAMA Neurology

Nov 11, 2019

Richard M TsaiAdam L. Boxer

PMID: 31710340

DOI: 10.1001/jamaneurol.2019.3812

Abstract

Basket-design clinical trials that allow investigation of treatment effects on different clinical syndromes that share the same molecular pathophysiology have not previously been attempted in neurodegenerative disease. To assess the safety, tolerability, and pharmacodynamics of the micr...read more

Mentioned in this Paper

Alzheimer's Disease
Biological Markers
Cerebrospinal Fluid
Clinical Trials
Double-Blind Method
19
1

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Paper Details
References
  • References28
  • Citations
123
  • References28
  • Citations
  • quote and clock

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