Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

Journal of Clinical Medicine
Konstantinos SfakianoudisKonstantinos Pantos

Abstract

Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot studies were conducted on poor ovarian response (POR), premature ovarian insufficiency (POI), perimenopause, and menopause, respectively. Each pilot study reports on thirty patients, 120 participants were recruited in total. All participants provided written informed consent prior to treatment. Primary outcome measures for the POR pilot study were levels of anti-müllerian hormone (AMH), antral follicle count (AFC) and oocyte yield. For the POI, perimenopausal and menopausal pilot studies primary outcome measures were restoration of menstrual cycle, and Follicle Stimulating Hormone (FSH) levels. A significant improvement on the hormonal profile and the ovarian reserve status was noted, along with improved intracytoplasmic sperm injection (ICSI) cycle performance concerning POR participants. Menstruation recovery was observed in 18 out of 30 POI patients, along with a statistically significant improvement on levels o...Continue Reading

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Citations

Sep 17, 2020·Diagnostics·Polina GiannelouKonstantinos Sfakianoudis
Jan 12, 2021·Climacteric : the Journal of the International Menopause Society·R Rosario, R A Anderson
Mar 16, 2021·Frontiers in Endocrinology·Alba M PolonioSonia Herraiz
May 9, 2021·Human Reproduction·Lloyd AtkinsonRoger G Sturmey
May 29, 2021·Annals of the New York Academy of Sciences·Agni PantouKonstantinos Sfakianoudis
Jul 8, 2021·Reproductive Sciences·Zaher MerhiMarco Mouanness
Feb 6, 2022·Reproductive Biology and Endocrinology : RB&E·Qiao-Yi HuangShu Lin

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Methods Mentioned

BETA
pregnancy test
sedation
blood collection
contraception

Clinical Trials Mentioned

NCT03937661
NCT03951194
NCT04031456
NCT03916978

Software Mentioned

R Programming Language for Statistical Purposes

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