Reactivation of Chlamydia pneumoniae infection in mice by cortisone treatment.

Infection and Immunity
K LaitinenP Saikku

Abstract

Reactivation of Chlamydia pneumoniae infection was studied by inducing immunosuppression by cortisone acetate treatment given every other day for 14 days in intranasally infected NIH/s mice. The treatment started 2 or 4 weeks after primary infection, when no C. pneumoniae was detected. C. pneumoniae could be recovered from the lung cultures on days 7 and 9 in 10 and 60% of the mice, respectively, when cortisone treatment was begun 30 days after infection. These results confirm the persistent nature of C. pneumoniae infection.

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Citations

Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·Shusaku HaranagaYoshimasa Yamamoto
Feb 28, 2003·Epidemiology·Kassandra L MungerAlberto Ascherio
Jan 7, 2003·Scandinavian Journal of Clinical and Laboratory Investigation·J MüllerE B Pedersen
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