Reactivation of fear memory renders consolidated amygdala synapses labile.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jeongyeon KimSukwoo Choi

Abstract

It is believed that memory reactivation transiently renders consolidated memory labile and that this labile or deconsolidated memory is reconsolidated in a protein synthesis-dependent manner. The synaptic correlate of memory deconsolidation upon reactivation, however, has not been fully characterized. Here, we show that 3,5-dihydroxyphenylglycine (DHPG), an agonist for group I metabotropic glutamate receptors (mGluRI), induces synaptic depotentiation only at thalamic input synapses onto the lateral amygdala (T-LA synapses) where synaptic potentiation is consolidated, but not at synapses where synaptic potentiation is not consolidated. Using this mGluRI-induced synaptic depotentiation (mGluRI-depotentiation) as a marker of consolidated synapses, we found that mGluRI-depotentiation correlated well with the state of memory deconsolidation and reconsolidation in a predictable manner. DHPG failed to induce mGluRI-depotentiation in slices prepared immediately after reactivation when the reactivated memory was deconsolidated. DHPG induced mGluRI-depotentiation 1 h after reactivation when the reactivated memory was reconsolidated, but it failed to do so when reconsolidation was blocked by a protein synthesis inhibitor. To test the memo...Continue Reading

Citations

Aug 3, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M OtisDevin Mueller
Aug 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sue-Hyun LeeBong-Kiun Kaang
May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ingie HongSukwoo Choi
Jun 30, 2012·PloS One·E J Marijke AchterbergLouk J M J Vanderschuren
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James M OtisDevin Mueller
Aug 11, 2012·Progress in Neurobiology·Antoine BesnardSerge Laroche
Apr 10, 2012·Neuroscience and Biobehavioral Reviews·Peter S B Finnie, Karim Nader
Mar 10, 2011·Biochemical and Biophysical Research Communications·Sukwon LeeSukwoo Choi
Oct 20, 2010·Annals of the New York Academy of Sciences·David A Silbersweig
Aug 30, 2012·The European Journal of Neuroscience·Yoshiko YamasakiHiroshi Nomura
Oct 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Filomene G MorrisonKerry J Ressler
Jun 18, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jihye KimSukwoo Choi
Apr 16, 2016·Trends in Neurosciences·Roger L Clem, Daniela Schiller
May 12, 2015·Trends in Pharmacological Sciences·Miao-Kun SunDaniel L Alkon
Nov 1, 2011·Cell·Joshua P JohansenJoseph E LeDoux
Nov 5, 2016·Neurobiology of Learning and Memory·Emily HughesKen Lukowiak
Oct 16, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M OtisDevin Mueller
Apr 12, 2011·Reviews in the Neurosciences·Ingie HongSukwoo Choi
Feb 26, 2020·Annual Review of Neuroscience·Josué HaubrichKarim Nader
May 21, 2013·Learning & Memory·Daisuke NakayamaHiroshi Nomura

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