Reactivation of herpes simplex virus after decompression of the trigeminal nerve root

The Journal of Infectious Diseases
G J PazinP J Jannetta

Abstract

Reactivation of herpes simplex virus was prospectively studied in patients after microneurosurgical decompression of the trigeminal sensory root, a new operation for trigeminal neuralgia in which the nerve is not sectioned. Reactivation was detected in 28 (50%) of 56 patients. Virus was cultured from oropharyngeal secretions in 25 patients, and 21 patients developed cutaneous herpetic lesions. Seven patients had positive throat-wash (TW) cultures but did not develop lesions, and the converse occurred in three patients. Eighteen patients had both positive TW cultures and herpetic lesions. In eight of nine instances in which a sequence was determinable, TW cultures were positive before lesions developed. A history of recurrent herpes labialis was associated with a higher risk of developing reactivation postoperatively (59.4% vs. 31.6%, P less than 0.05). These observations suggest that minimal stimulation or inapparent trauma to the trigeminal sensory root is sufficient to activate latent herpes simplex virus in humans. These patients provide unique opportunities to study immunologic responses and therapeutic measures.

Citations

Jan 1, 1993·Journal of Medical Virology·S L Spruance
Feb 24, 2001·Transactions of the American Ophthalmological Society·P A Asbell
Apr 1, 1996·Dermatologic Clinics·C S Miller
Mar 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·J B Cavanagh, P H Buxton
Aug 16, 2002·American Journal of Clinical Dermatology·Arjen F Nikkels, Gérald E Pièrard
Aug 15, 1994·American Journal of Ophthalmology·W S ThompsonJ T Rosenbaum
Mar 12, 2004·American Journal of Ophthalmology·Renata A RezendeElisabeth J Cohen
Mar 1, 1987·Antimicrobial Agents and Chemotherapy·D Gold, L Corey
Apr 1, 1995·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·F J Jenkins, A Baum
Jan 3, 2016·World Neurosurgery·Assaf BergerNevo Margalit
Nov 1, 1990·Journal of the American Academy of Dermatology·D GroisserM E Grossman
Sep 1, 1981·Journal of the American Academy of Dermatology·B Raab, A L Lorincz
Oct 18, 2007·Journal of the American Academy of Dermatology·Mahnaz Fatahzadeh, Robert A Schwartz
Feb 6, 2013·The Laryngoscope·Joshua J ThomColin L W Driscoll
Apr 1, 1984·Clinics in Dermatology·W E Rawls, O Hammerberg
Sep 9, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Valérie Franco-VidalVincent Darrouzet
Dec 1, 1982·Journal of the American Academy of Dermatology·B H Thiers
Nov 21, 1998·The Annals of Otology, Rhinology, and Laryngology·V BonkowskyW Arnold
Jul 13, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·J J Shea, X Ge
Jul 3, 2003·The Laryngoscope·Jeffrey T VrabecHerman A Jenkins
May 3, 2000·International Ophthalmology Clinics·B D GaynorE T Cunningham
May 1, 1986·Annals of Neurology·J P DickM P Sheehy
May 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·E HednerJ M Hirsch
Apr 11, 2007·Acta Neurologica Scandinavica. Supplementum·P Monstad
Nov 3, 2005·Current Opinion in Ophthalmology·M Tariq Bhatti, Rachana Patel
Feb 9, 2000·The Journal of Laryngology and Otology·K Gyo, N Honda
Aug 23, 2002·International Ophthalmology Clinics·Jonathan C Horton
Feb 3, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jonas EckermannThomas Guenzel
May 1, 1984·Journal of Clinical Microbiology·S L Spruance
Apr 1, 1993·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·E HednerJ M Hirsch

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