Reactivation of polyomavirus in the genitourinary tract is significantly associated with severe GvHD and oral mucositis following allogeneic stem cell transplantation

Infection
Lisa PetersonChristina T Rieger

Abstract

BK-virus and JC-virus are the most common polyomaviridae associated with hemorrhagic cystitis in the allogeneic transplant setting. Hemorrhagic cystitis and symptomatic viruria caused by these viruses are a major cause of morbidity in patients undergoing allogeneic stem cell transplantation. We performed a retrospective evaluation on a highly uniform study population of 73 patients receiving allogeneic stem cell transplantation. Patients were treated according to the FLAMSA-RIC-protocol, and were examined for the incidence of BK-/JC-viruria and late-onset BK-positive hemorrhagic cystitis within a two-year period. The occurrence of BK-viruria was correlated with published risk factors (acute GvHD, oral mucositis, donor type, conditioning, age, gender). Thirty patients (41 %) were found to excrete either BK-virus (n = 17), JC-virus (n = 3) or both (n = 10), of whom 18 patients (60 %) developed higher-grade hemorrhagic cystitis as opposed to none in the virus-negative control group. Higher grade GvHD (grade B-D) was more common in patients with viruria (p = 0.013) and also more common in patients with manifest hemorrhagic cystitis (p = 0.048). Similarly, oral mucositis was associated both with viruria (p = 0.014) and hemorrhagic c...Continue Reading

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Citations

Apr 13, 2017·European Journal of Haematology·Konstantin HöllerVeronica Di Cristanziano
Sep 30, 2016·World Journal of Transplantation·Darlene VigilAntonios H Tzamaloukas
May 6, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Lucila Nassif KerbauyFabio Pires de Souza Santos
Sep 30, 2017·American Journal of Hematology·Laila SchneidewindWilliam Krüger
Jun 3, 2021·Microorganisms·Carla PreziosoUgo Moens
Jan 4, 2019·Acta Haematologica·Laila SchneidewindWilliam Krüger

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