Reactivation of recipient antibody to blood cell antigens soon after allogeneic bone marrow transplantation

Vox Sanguinis
D WernetH Northoff

Abstract

Reactivation of recipient antibody to HLA and red blood cell antigens is described in 8 patients after allogeneic bone marrow transplantation. These IgG antibodies can be detected between day 10 and day 40 after transplantation and, in 1 patient, can be shown to be antigen-independent. We hypothesize that, induced by graft recognition of recipient antigens, antigen-independent activation of sensitized recipient B cells takes place leading to transient antibody production.

Citations

Sep 5, 2009·Current Opinion in Hematology·Sandra Taddie Nance

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