Reactivation of tuberculosis during temsirolimus therapy.

Investigational New Drugs
Romain CoriatFrançois Goldwasser

Abstract

Reactivation of tuberculosis is rare in patients receiving chemotherapy for solid tumours, and poorly documented in patients receiving molecular targeted therapy. We report on a patient with metastatic renal-cell carcinoma treated with temsirolimus, who developed respiratory symptoms and mild fever after 6 weeks of treatment. CT-scan and laboratory tests were consistent with reactivation of tuberculosis. The patient received anti-tuberculosis therapy including rifampicin, a potent CYP3A4/5 inducer. After introduction of rifampicin-based treatment, the patient experienced tumour progression, leaving questionable the potential pharmacokinetic interaction between rifampicin and temsirolimus, a substrate for CYP3A4.

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Citations

Sep 26, 2012·Onkologie·MinYuen TeoDerek G Power
Aug 31, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chia-Chi LinYeong-Shiau Pu
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chia-Chi LinYeong-Shiau Pu
Sep 25, 2017·Nature Reviews. Drug Discovery·Stefan H E KaufmannRalf Bartenschlager
Feb 29, 2020·Infection and Drug Resistance·Elaheh Kordzadeh-KermaniMohammadreza Salehi

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